{
  "abstract": "Dipeptidyl peptidase-4 (DPP4) is involved in immune regulation and metabolic homeostasis. Although DPP4 inhibitors are widely used in type 2 diabetes, the clinical relevance of autoantibodies against DPP4 (DPP4-Ab) remains unclear. In this study, we aimed to investigate the association between circulating DPP4-Ab levels and mortality in 274 patients with type 2 diabetes (mean age, 63 years). Serum DPP4-Ab levels were measured using amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA), and survival was assessed using Kaplan-Meier analysis and Cox proportional hazards regression analysis. During a mean follow-up of approximately 5 years, 32 deaths had occurred. Patients with elevated DPP4-Ab titers (>1,676.8 alpha counts) had a higher mortality rate than those with low titers (22.2% vs. 9.3%, p = 0.0177). In Cox proportional hazards regression analysis, DPP4-Ab titers showed a trend toward association with all-cause mortality when analyzed as a continuous variable per 100 alpha counts (a.c.) increase (hazard ratio [HR], 1.042; 95% confidence interval [CI], 0.996-1.090; p = 0.071). When patients were stratified using the predefined cutoff value of 1,676.8 a.c., the high DPP4-Ab group showed significantly higher mortality risk than the low DPP4-Ab group (HR, 2.30; 95% CI, 1.09-4.84; p = 0.028). Addition of DPP4-Ab to an age-based model only slightly improved predictive discrimination. These findings suggest that elevated DPP4-Ab titers may be associated with mortality risk; however, this association should be interpreted cautiously and warrants further investigation as a potential adjunctive immunometabolic biomarker in type 2 diabetes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Takeshi Yagihashi"
    },
    {
      "name": "Takahide Hashimoto"
    },
    {
      "name": "Naoki Ohtake"
    },
    {
      "name": "Tokiko Okamoto"
    },
    {
      "name": "Bo-Shi Zhang"
    },
    {
      "name": "Yoichi Yoshida"
    },
    {
      "name": "Masaya Yamaga"
    },
    {
      "name": "Tomohiko Yoshida"
    },
    {
      "name": "Amika Kajiyama"
    },
    {
      "name": "Rikako Furukawa"
    },
    {
      "name": "Takaki Hiwasa"
    },
    {
      "name": "Minoru Takemoto"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9r6rp4qc7776p.bib",
  "cited_by": 0,
  "doi": "10.1507/endocrj.ej26-0170",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ26-0170/_article",
  "id": "9r6rp4qc7776p",
  "issns": [
    "1348-4540",
    "0918-8959"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ26-0170/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/endocrinology-metabolism"
    ],
    [
      "openalex",
      "2712|Diabetes Treatment and Management"
    ]
  ],
  "openalex": "W7169865905",
  "pdf_url": "https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ26-0170/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9r6rp4qc7776p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "10.1507/endocrj.ej26-0170",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/endocrj/73/11/73_EJ26-0170/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Diabetes Treatment and Management",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Elevated autoantibodies against dipeptidyl peptidase-4 are associated with poor prognosis in patients with type 2 diabetes",
  "title_text": "Elevated autoantibodies against dipeptidyl peptidase-4 are associated with poor prognosis in patients with type 2 diabetes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:49Z",
  "url": "https://research.draconitic.com/paper/9r6rp4qc7776p",
  "venue": "Endocrine Journal",
  "versions": []
}