{
  "abstract": "To investigate the association between intraoperative blood loss and postoperative major complications in patients undergoing emergency surgery for colorectal perforation. This single-center retrospective observational study included 138 patients who underwent emergency surgery for colorectal perforation. Patients were classified into two groups based on intraoperative blood loss: ≥200 mL and <200 mL. The primary outcome was major complications defined as Clavien-Dindo grade ≥3 (including in-hospital death). Multivariable logistic regression analysis was performed to identify independent risk factors. Restricted cubic spline analysis was used to assess the dose-response relationship. Major complications occurred in 45 patients (32.6%). Patients with blood loss ≥200 mL had a significantly higher rate of major complications compared with those with blood loss <200 mL (51.5% vs. 15.3%; p < 0.001). Multivariable analysis identified intraoperative blood loss ≥200 mL (adjusted odds ratio [OR], 4.21; 95% confidence interval [CI], 1.75-10.75; p = 0.002) and preoperative hypotension requiring vasopressor use (adjusted OR, 6.70; 95% CI, 2.47-20.01; p < 0.001) as independent risk factors. Restricted cubic spline analysis confirmed a dose-dependent relationship. Intraoperative blood loss ≥200 mL was independently associated with major complications in emergency colorectal perforation surgery. Whether reducing intraoperative blood loss improves postoperative outcomes warrants further investigation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Trauma and Emergency Surgery, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ikutaro Yamashita"
    },
    {
      "affs": [
        0
      ],
      "name": "Shokei Matsumoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Masayuki Shimizu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9rd9334109j9d.bib",
  "cited_by": 0,
  "doi": "10.23922/jarc.2026-056",
  "fulltext_url": "https://europepmc.org/articles/PMC13713558",
  "id": "9rd9334109j9d",
  "issns": [
    "2432-3853"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952669",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "lcc",
      "RC799-869"
    ],
    [
      "openalex",
      "2730|Colorectal Cancer Surgical Treatments"
    ]
  ],
  "openalex": "W7223449206",
  "pdf_url": "https://europepmc.org/articles/PMC13713558?pdf=render",
  "pmcid": "PMC13713558",
  "pmid": "42952669",
  "published": "2026-10-25",
  "publisher": "The Japan Society of Coloproctology",
  "ris": "https://research.draconitic.com/paper/9rd9334109j9d.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:40Z",
      "native_id": "MED:42952669",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952669"
    },
    {
      "first_seen": "2026-10-31T12:24:05Z",
      "native_id": "PMC13713558",
      "source": "pmc",
      "url": "https://doi.org/10.23922/jarc.2026-056"
    },
    {
      "first_seen": "2026-10-31T14:22:05Z",
      "native_id": "04ff009f24304772bd9dca5f3d1cdfbc",
      "source": "doaj",
      "url": "https://doi.org/10.23922/jarc.2026-056"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Colorectal Cancer Surgical Treatments",
      "subfield": "oncology"
    }
  ],
  "title": "Association between Intraoperative Blood Loss and Postoperative Outcomes in Colorectal Perforation: A Retrospective Observational Study in Japan.",
  "title_text": "Association between Intraoperative Blood Loss and Postoperative Outcomes in Colorectal Perforation: A Retrospective Observational Study in Japan.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:12Z",
  "url": "https://research.draconitic.com/paper/9rd9334109j9d",
  "venue": "Journal of the anus, rectum and colon",
  "versions": []
}