{
  "abstract": "Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder typically recognized during adolescence because of absent or incomplete pubertal development. We report the case of an 89-year-old man admitted for an ischemic stroke whose physical examination revealed a high-pitched voice, markedly sparse facial and axillary hair, bilateral gynecomastia, a markedly reduced penile size clinically suggestive of micropenis, and nonpalpable testes in the scrotum. Hormonal evaluation showed a total testosterone concentration below 7.00 ng/dL, luteinizing hormone below 0.07 IU/L, and follicle-stimulating hormone of 0.83 IU/L, consistent with severe central hypogonadism. Ultrasonography demonstrated both testes within the inguinal canals with reduced testicular size. Magnetic resonance imaging (MRI) of the sellar region showed no structural hypothalamic-pituitary abnormality. Although advanced age and acute systemic illness may have contributed to further functional suppression of the hypothalamic-pituitary-gonadal axis, these factors could not account for the developmental genital abnormalities. Integration of the phenotypic, biochemical, and imaging findings supported a clinical diagnosis of previously unrecognized CHH. This case illustrates an exceptionally late recognition of CHH and highlights the diagnostic value of developmental phenotypic features in identifying a congenital disorder that may remain unrecognized for decades.",
  "abstract_shown": true,
  "affiliations": [
    "Internal Medicine, Unidade Local de Saúde de Castelo Branco, Castelo Branco, PRT."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mafalda Ferreira"
    },
    {
      "affs": [
        0
      ],
      "name": "Patrícia O Saraiva"
    },
    {
      "affs": [
        0
      ],
      "name": "Franciso Nunes"
    },
    {
      "affs": [
        0
      ],
      "name": "João Cardoso"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Eugénia André"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9re5d5hg084rg.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116742",
  "fulltext_url": "https://europepmc.org/articles/PMC13688578",
  "id": "9re5d5hg084rg",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924005",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2743|Hypothalamic control of reproductive hormones"
    ]
  ],
  "openalex": "W7214005990",
  "pdf_url": "https://europepmc.org/articles/PMC13688578?pdf=render",
  "pmcid": "PMC13688578",
  "pmid": "42924005",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9re5d5hg084rg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42924005",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924005"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Hypothalamic control of reproductive hormones",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Previously Unrecognized Congenital Hypogonadotropic Hypogonadism in an 89-Year-Old Man: A Case Report.",
  "title_text": "Previously Unrecognized Congenital Hypogonadotropic Hypogonadism in an 89-Year-Old Man: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/9re5d5hg084rg",
  "venue": "Cureus",
  "versions": []
}