{
  "abstract": "Objective\n\nTo evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphism and postoperative pain intensity and rescue analgesic requirements in thoracotomy patients receiving pre-emptive pregabalin versus naproxen.Methods\n\nIn this prospective randomized trial, 40 ASA I-II adults undergoing elective thoracotomy were randomized to pre-emptive oral pregabalin (2.5 mg/kg, n = 20) or naproxen (7 mg/kg, n = 20). All received standardized thoracic epidural and general anesthesia. COMT rs4633 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Postoperative numerical rating scale (NRS) pain scores and 24-hour rescue analgesia requirements were recorded.Results\n\nThe distribution of COMT genotypes was similar between groups (P = 0.74). Mean NRS scores were lower in Group I compared to Group II at 2 hours (3.6 ± 1.1 vs 4.0 ± 1.2), 6 hours (3.1 ± 1.0 vs 3.5 ± 1.1), 12 hours (2.7 ± 0.9 vs 3.0 ± 1.0), and 24 hours (2.5 ± 0.9 vs 2.8 ± 1.0), with no statistically significant difference (P > 0.05). At 24 hours, CT genotype patients showed higher pain scores than CC and TT genotypes in both groups (Group I: 2.9 ± 1.0; Group II: 3.1 ± 1.1). Rescue analgesia was required in 30% of Group I and 45% of Group II patients. Time to first rescue analgesia was longer in Group I (8.6 ± 3.2 h vs 7.4 ± 3.1 h), with fewer rescue doses [median 0 (IQR 0-1) vs 1 (IQR 0-2)].Conclusion\n\nDespite non-significant results, CT genotype showed higher pain and analgesic needs, while pregabalin demonstrated a clinically favorable trend over naproxen.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anaesthesiology, UPUMS, Etawah, Uttar Pradesh, India.",
    "Department of Anaesthesiology, King George Medical University, Uttar Pradesh, India.",
    "Department of Anaesthesiology, Kalyan Singh Cancer Institute, Lucknow, Uttar Pradesh, India."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Prajjal Das"
    },
    {
      "affs": [
        1
      ],
      "name": "Rajni Gupta"
    },
    {
      "affs": [
        2
      ],
      "name": "Vaishali Singh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9rxxxasmcgtdp.bib",
  "cited_by": 0,
  "doi": "10.4103/sja.sja_444_26",
  "fulltext_url": "https://europepmc.org/articles/PMC13719069",
  "id": "9rxxxasmcgtdp",
  "issns": [
    "1658-354X",
    "0975-3125"
  ],
  "landing_url": "https://europepmc.org/article/MED/42960024",
  "language": "eng",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2746|Anesthesia and Pain Management"
    ]
  ],
  "openalex": "W7215074139",
  "pdf_url": "https://europepmc.org/articles/PMC13719069?pdf=render",
  "pmcid": "PMC13719069",
  "pmid": "42960024",
  "published": "2026-10-01",
  "publisher": "Wolters Kluwer -- Medknow Publications",
  "ris": "https://research.draconitic.com/paper/9rxxxasmcgtdp.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42960024",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960024"
    },
    {
      "first_seen": "2026-11-02T12:22:58Z",
      "native_id": "PMC13719069",
      "source": "pmc",
      "url": "https://doi.org/10.4103/sja.sja_444_26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Anesthesia and Pain Management",
      "subfield": "surgery"
    }
  ],
  "title": "Effect of COMT gene polymorphism on post-thoracotomy pain and analgesic requirements in patients receiving multimodal pre-emptive analgesia with pregabalin versus naproxen: A randomized clinical trial.",
  "title_text": "Effect of COMT gene polymorphism on post-thoracotomy pain and analgesic requirements in patients receiving multimodal pre-emptive analgesia with pregabalin versus naproxen: A randomized clinical trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:58Z",
  "url": "https://research.draconitic.com/paper/9rxxxasmcgtdp",
  "venue": "Saudi journal of anaesthesia",
  "versions": []
}