{
  "abstract": "PurposeMen with pathogenic BRCA1 and BRCA2 variants (BRCA+) have an elevated lifetime risk of male breast cancer (MBC) yet data regarding mammography in this population remain limited.\n\nMethodsWe performed a retrospective cohort study of BRCA+ assigned male at birth individuals (males) at Penn (1/1/2008-5/1/2024) and the Veterans Administration (VA, 10/1/2002-1/1/2026) for mammography uptake. Mammography results and MBC characteristics were compared between BRCA+ and BRCA-males.\n\nResultsAmong 810 BRCA+ males, 19% had a documented mammogram for screening or symptoms. Among 562 BRCA+ males age-eligible for mammogram without prior MBC, most (63%) had documentation of a mammography-related discussion and 16% completed mammogram, of whom 25% were BRCA1+ and 75% were BRCA2+. Among mammograms obtained for screening of 97 BRCA+ males, there were few BI-RADS 4/5 (N=1, 1%) and no MBC was detected. Symptom-indicated mammograms in 59 BRCA+ compared to 228 BRCA-males yielded BI-RADS 4/5 findings in 35% versus 25%, p<0.0001, and MBC diagnoses in 29% versus 21%, p=0.219. The positive predictive value (PPV) of BI-RADS 4/5 lesions was similar in BRCA+ vs BRCA-males (71% vs 74% and 100% vs 93%, respectively). Among 22 BRCA+ and 57 BRCA-MBC, 55% and 42% were node positive and 82% and 86% were ER+Her2-, respectively.\n\nConclusionScreening mammography utilization among BRCA+ males was low despite elevated hereditary risk. Regardless of BRCA status, nearly all MBC were diagnosed based on symptoms, and a high proportion of MBC were diagnosed at advanced stages. Our findings identify a critical need for both improved identification of males at high risk for breast cancer and improved screening practices of high-risk men.",
  "abstract_shown": true,
  "affiliations": [
    "Corporal Michael J Crescenz VA Medical Center"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 28,
  "authors": [
    {
      "name": "M. Y. Davies"
    },
    {
      "name": "M. Tayeb"
    },
    {
      "name": "E. Scarrow"
    },
    {
      "name": "J. Phun"
    },
    {
      "name": "E. Milavsky"
    },
    {
      "name": "C. Orr"
    },
    {
      "name": "R. Sore"
    },
    {
      "name": "D. Lu"
    },
    {
      "name": "H. Symecko"
    },
    {
      "name": "S. Ehsan"
    },
    {
      "name": "H. Desai"
    },
    {
      "name": "R. Hausler"
    },
    {
      "name": "B. Wubbenhorst"
    },
    {
      "name": "A. Doucette"
    },
    {
      "name": "P. Gabriel"
    },
    {
      "name": "K. L. Nathanson"
    },
    {
      "name": "C. Edmonds"
    },
    {
      "name": "K. W. Robinson"
    },
    {
      "name": "M. J. Kelley"
    },
    {
      "name": "I. P. Garraway"
    },
    {
      "name": "L. L. Zullig"
    },
    {
      "name": "E. M. Bayley"
    },
    {
      "name": "H. A. Moss"
    },
    {
      "name": "M. W. Schoen"
    },
    {
      "name": "A. M. McCarthy"
    },
    {
      "name": "S. M. Domchek"
    },
    {
      "name": "J. Q. Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "K. N. Maxwell"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9s2h77bkk07pr.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.22.26363613",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.22.26363613v1.full",
  "id": "9s2h77bkk07pr",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.22.26363613v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "oncology"
    ],
    [
      "openalex",
      "2739|Male Breast Health Studies"
    ]
  ],
  "openalex": "W7214122215",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.22.26363613v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9s2h77bkk07pr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:18Z",
      "native_id": "10.64898/2026.09.22.26363613",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.22.26363613v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:oncology",
      "subfield": "oncology"
    }
  ],
  "title": "Mammography utilization and male breast cancer in BRCA1/2 carriers",
  "title_text": "Mammography utilization and male breast cancer in BRCA1/2 carriers",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:18Z",
  "url": "https://research.draconitic.com/paper/9s2h77bkk07pr",
  "venue": "medRxiv",
  "versions": []
}