{
  "abstract": "Background\n\nSelf-management behaviors are central to long-term care for chronic hepatitis B (CHB), but the independent associations of social support and disease-specific quality-of-life domains with self-management remain unclear. This study assessed self-management and its associated factors among patients with CHB.Methods\n\nThis multicenter cross-sectional study included 583 patients with CHB recruited by convenience sampling at three tertiary hospitals in Hengyang, China, from March to October 2025. Participants completed the Chronic Hepatitis B Self-Management Scale (CHBSMS), Social Support Rating Scale (SSRS), and Chronic Hepatitis B Quality of Life Instrument (CHBQOL). Hierarchical multiple linear regression, HC3 robust standard errors, and sensitivity analyses were used.Results\n\nThe mean total CHBSMS score was 85.03 ± 19.38. The sociodemographic model yielded an R ² of 0.194. Adding clinical and healthcare utilization factors increased the explained variance (ΔR ² = 0.083), and adding social support and the four CHBQOL domain scores further increased the explained variance (ΔR ² = 0.102), yielding a final R ² of 0.379. In the fully adjusted model, social support (B = 0.577, 95% CI: 0.416-0.739, p < 0.001), the emotional symptoms domain (B = 0.170, 95% CI: 0.039-0.301, p = 0.011), and the social stigma domain (B = 0.235, 95% CI: 0.082-0.388, p = 0.003) were positively associated with self-management scores. Higher scores in the latter two domains indicated fewer emotional symptoms and less social stigma, respectively. For a 1-SD higher value of each predictor, the corresponding CHBSMS differences were 4.79, 1.90, and 2.15 points for social support, emotional symptoms, and social stigma, respectively, equivalent to 4.79, 1.90, and 2.15% of the score range. The somatic symptoms and belief domains were not significantly associated with self-management. Robustness and sensitivity analyses did not materially alter the main findings.Conclusion\n\nAmong patients with CHB recruited from three tertiary hospitals, social support, the emotional symptoms domain, and the social stigma domain were associated with self-management after adjustment for sociodemographic, clinical, and healthcare utilization factors. Further longitudinal research is needed to clarify the temporal direction and clinical relevance of these associations.",
  "abstract_shown": true,
  "affiliations": [
    "Department of International and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China, Hengyang, China.",
    "The First Affiliated Hospital, Department of Gastroenterology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.",
    "Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wen-Ting Yi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ling-Ling Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Mao-Ting Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui-Ling Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Jia-Jun Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi-Jing Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao-Yan Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing-Zhi Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ke-Hao Zhao"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Ying Zeng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9s3fjmmwxzmg6.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1962656",
  "fulltext_url": "https://europepmc.org/articles/PMC13683648",
  "id": "9s3fjmmwxzmg6",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908953",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Hepatitis B Virus Studies"
    ]
  ],
  "openalex": "W7220865542",
  "pdf_url": "https://europepmc.org/articles/PMC13683648?pdf=render",
  "pmcid": "PMC13683648",
  "pmid": "42908953",
  "published": "2026-10-07",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9s3fjmmwxzmg6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42908953",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908953"
    },
    {
      "first_seen": "2026-10-30T12:20:22Z",
      "native_id": "10.3389/fpubh.2026.1962656",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1962656/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Hepatitis B Virus Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Associations of social support and disease-specific quality of life with self-management among patients with chronic hepatitis B: a multicenter cross-sectional study.",
  "title_text": "Associations of social support and disease-specific quality of life with self-management among patients with chronic hepatitis B: a multicenter cross-sectional study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:22Z",
  "url": "https://research.draconitic.com/paper/9s3fjmmwxzmg6",
  "venue": "Frontiers in public health",
  "versions": []
}