{
  "abstract": "Drug addiction involves profound modifications of neuronal plasticity in the nucleus accumbens, which may engage various cell types. Here, we report prominent effects of cocaine on calcium signals in astrocytes characterized by in vivo fiber photometry. Astrocyte calcium signals in the nucleus accumbens are sufficient and necessary for the acquisition of cocaine seeking behavior. We identify the astrocyte-secreted matricellular protein hevin as an effector of the action of cocaine and calcium signals on reward and neuronal plasticity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "name": "Raphaële Mongrédien"
    },
    {
      "name": "Augusto Anesio"
    },
    {
      "name": "Gustavo J.D. Fernandes"
    },
    {
      "name": "Andrew Eagle"
    },
    {
      "name": "Steeve Maldera"
    },
    {
      "name": "Cuong Pham"
    },
    {
      "name": "Séverine Robert"
    },
    {
      "name": "Fernando Bezerra"
    },
    {
      "name": "Adèle Vilette"
    },
    {
      "name": "Paula Bianchi"
    },
    {
      "name": "Clara Franco"
    },
    {
      "name": "Franck Louis"
    },
    {
      "name": "Carole Gruszczynski"
    },
    {
      "name": "Marie-Laure Niépon"
    },
    {
      "name": "Catalina Betancur"
    },
    {
      "name": "Amaia Erdozain"
    },
    {
      "name": "Alfred Robison"
    },
    {
      "name": "Antony Boucard"
    },
    {
      "name": "Fabio Cruz"
    },
    {
      "name": "Dongdong Li"
    },
    {
      "name": "Nicolas Heck"
    },
    {
      "name": "Sophie Gautron"
    },
    {
      "name": "Vincent Vialou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9s4aqwvmddryr.bib",
  "cited_by": 9,
  "doi": "10.1016/j.biopsych.2025.02.904",
  "fulltext_url": null,
  "id": "9s4aqwvmddryr",
  "issns": [
    "0006-3223"
  ],
  "landing_url": "https://hal.science/hal-05780246v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "hal",
      "2.sdv.neu.nb"
    ],
    [
      "openalex",
      "2804|Neurotransmitter Receptor Influence on Behavior"
    ]
  ],
  "openalex": "W4408566771",
  "pdf_url": "https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)01072-8/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/9s4aqwvmddryr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:48Z",
      "native_id": "hal-05780246",
      "source": "hal",
      "url": "https://hal.science/hal-05780246v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.neu",
      "subfield": "neuroscience"
    }
  ],
  "title": "Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin",
  "title_text": "Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:48Z",
  "url": "https://research.draconitic.com/paper/9s4aqwvmddryr",
  "venue": "Biological Psychiatry",
  "versions": []
}