{
  "abstract": "Xanthine dehydrogenase (XDH) is involved in the progression of various cancer. This study aimed to investigate its potential in colorectal cancer (CRC). Gene expression was determined using RT-qPCR, Western blot, immunohistochemistry, and immunofluorescence. Cell behaviors were analyzed using CCK-8, colony formation, wound healing, transwell migration, TUNEL, PI staining. In vivo assay was conducted to verify the role of XDH in CRC. Histological analysis was performed using HE staining. We found that XDH was downregulated in CRC. XDH overexpression suppressed proliferation and aggressiveness of CRC cells, whereas XDH knockdown exerted opposite effects. XDH selectively increased purine metabolites and promoted impairment of mitochondrial metabolism. Mechanistically, XDH activated NCOA4-dependent ferritinophagy signaling and drove CRC cells to ferroptosis, which was reversed by 3-MA. Taken together, XDH inhibits the progression of CRC via mediating ferritinophagy and ferroptosis. Therefore, XDH/ferritinophagy may be a potential target for CRC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.",
    "Department of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan, China.",
    "Department of Oncology, Huaihe Hospital of Henan University, Kaifeng, Henan, China.",
    "Department of General surgery, The First Affiliated Hospital of Henan University, Kaifeng, Henan, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Huiying Zhang",
      "orcid": "0009-0003-5738-2599"
    },
    {
      "affs": [
        0
      ],
      "name": "Meimei Yan"
    },
    {
      "affs": [
        1
      ],
      "name": "Mengya Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Junjiao Gu"
    },
    {
      "affs": [
        3
      ],
      "name": "Xintao Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jin Ding"
    },
    {
      "affs": [
        0
      ],
      "name": "Suxia Luo",
      "orcid": "0009-0006-6685-465X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9scgnxmsy93c1.bib",
  "cited_by": 0,
  "doi": "10.1002/jbt.71145",
  "fulltext_url": "https://europepmc.org/articles/PMC13695999",
  "id": "9scgnxmsy93c1",
  "issns": [
    "1095-6670",
    "1099-0461"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927618",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Ferroptosis and cancer prognosis"
    ]
  ],
  "openalex": "W7223562002",
  "pdf_url": "https://europepmc.org/articles/PMC13695999?pdf=render",
  "pmcid": "PMC13695999",
  "pmid": "42927618",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9scgnxmsy93c1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927618",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927618"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Ferroptosis and cancer prognosis",
      "subfield": "general"
    }
  ],
  "title": "XDH Inhibits the Progression of Colorectal Cancer via Regulating Ferritinophagy Signaling.",
  "title_text": "XDH Inhibits the Progression of Colorectal Cancer via Regulating Ferritinophagy Signaling.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/9scgnxmsy93c1",
  "venue": "Journal of biochemical and molecular toxicology",
  "versions": []
}