{
  "abstract": "During the COVID-19 pandemic, the use of cryopreserved grafts in allogeneic hematopoietic stem cell transplantation (HSCT) increased substantially. Dimethyl sulfoxide (DMSO), used as a cryoprotective agent, is well recognized for its infusion-related toxicity; however, its impact on cardiac function remains unclear.Methods\n\nThis prospective study included 96 consecutive patients (median age 46 years) undergoing allogeneic HSCT. Patients were divided according to graft type into cryopreserved (n = 59, 61.5%) and non-cryopreserved (n = 37, 38.5%) groups. Comprehensive echocardiographic assessment was performed before and after transplantation.Results\n\nSignificant changes were observed in diastolic parameters (E/A, and E/E'), structural parameters (left ventricular mass and left ventricular mass index), global longitudinal strain (GLS), and right ventricular ejection fraction following HSCT. In the cryopreserved group, E/A ratio decreased below the normal range and E/E' ratio increased significantly, whereas no such changes were observed in the non-cryopreserved group. During the 30-day follow-up period, symptomatic cardiovascular toxicity occurred in 5 patients (5.2%), while subclinical cancer therapy-related cardiac dysfunction was detected in 16 patients (16.7%). Receiver operating characteristic (ROC) analysis demonstrated that GLS predicted cardiotoxicity with an area under the curve (AUC) of 0.88 (95% CI, 0.79-0.98; p < 0.0001). At a cut-off value of - 16.8%, sensitivity was 100% and specificity was 79%.Conclusion\n\nCryopreserved graft administration may be associated with early alterations in left ventricular diastolic function, potentially reflecting DMSO-related cardiotoxicity. GLS appears to be a sensitive marker for the early detection and prediction of cardiotoxicity in patients undergoing allogeneic HSCT.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology and Transfusiology, Faculty of Medicine, Comenius University, University Hospital Bratislava, Bratislava, Slovakia.",
    "Department of Pathological Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.",
    "Department of Non-Invasive Cardiology, University Hospital Bratislava, Bratislava, Slovakia.",
    "Department of Hematology and Transfusiology, Faculty of Medicine, Comenius University, University Hospital Bratislava, Bratislava, Slovakia. lubica.harvanova@szu.sk.",
    "Department of Hematology and Transfusion Medicine, Faculty of Medicine, Slovak Medical University, University Hospital, Antolska 11, Bratislava, 85107, Slovakia. lubica.harvanova@szu.sk."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "V Lábska"
    },
    {
      "affs": [
        1
      ],
      "name": "B Mladosievičová"
    },
    {
      "affs": [
        2
      ],
      "name": "J Dúbrava"
    },
    {
      "affs": [
        0
      ],
      "name": "B Žiaková"
    },
    {
      "affs": [
        0
      ],
      "name": "K Nemergutová"
    },
    {
      "affs": [
        0
      ],
      "name": "L Sopko"
    },
    {
      "affs": [
        0
      ],
      "name": "J Lukáš"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Ľ Harvanová"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9sg280g8p2yd9.bib",
  "cited_by": 0,
  "doi": "10.1007/s12012-026-10207-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13668963",
  "id": "9sg280g8p2yd9",
  "issns": [
    "1530-7905",
    "1559-0259"
  ],
  "landing_url": "https://europepmc.org/article/MED/42875553",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
    ]
  ],
  "openalex": "W7222144523",
  "pdf_url": "https://europepmc.org/articles/PMC13668963?pdf=render",
  "pmcid": "PMC13668963",
  "pmid": "42875553",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9sg280g8p2yd9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42875553",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42875553"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Impact of Dimethyl Sulfoxide on Early Cardiotoxicity After Allogeneic Hematopoietic Stem Cell Transplantation.",
  "title_text": "Impact of Dimethyl Sulfoxide on Early Cardiotoxicity After Allogeneic Hematopoietic Stem Cell Transplantation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/9sg280g8p2yd9",
  "venue": "Cardiovascular toxicology",
  "versions": []
}