{
  "abstract": "The α-arylation of carbonyl compounds is a cornerstone transformation in the synthesis of pharmaceuticals and natural products. Despite decades of efforts using transition metal, main-group and photoredox strategies, a general and practical α-arylation method with broad substrate scope has remained elusive. Here we show that 9-bismatriptycene (BisTrip), a rigid, shackled form of triphenylbismuth, functions as a universal aryl group transporter, enabling controlled and regiospecific α-arylation of diverse ketones, allowing the formation of sterically demanding quaternary centres and incorporation of iodoaryl units. BisTrip is readily loaded with aryl groups by a one-pot procedure using arylboronic acids to give Aryl-BisTrip and, after transferring the aryl to the enolate, is recovered quantitatively. Arylation of lithium enolates proceeds within seconds even at −78 °C and shows high fidelity in a memory-of-chirality experiment. Computations support a low barrier for C−C bond formation and account for the observed axial selectivity, establishing BisTrip as a practical platform for α-arylation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, University of Chicago, Chicago, IL USA",
    "Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Li Li",
      "orcid": "0000-0002-1400-8025"
    },
    {
      "affs": [
        0
      ],
      "name": "Filippo Carpaneto",
      "orcid": "0009-0001-8228-7409"
    },
    {
      "affs": [
        1
      ],
      "name": "Pan-Pan Chen",
      "orcid": "0000-0002-3209-3841"
    },
    {
      "affs": [
        1
      ],
      "name": "K. N. Houk"
    },
    {
      "affs": [
        0
      ],
      "name": "Viresh H. Rawal",
      "orcid": "0000-0003-4606-0239"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9snbe3pffg3fn.bib",
  "cited_by": 1,
  "doi": "10.1038/s41557-026-02231-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13652010/",
  "id": "9snbe3pffg3fn",
  "issns": [
    "1755-4330",
    "1755-4349"
  ],
  "landing_url": "https://doi.org/10.1038/s41557-026-02231-5",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1605|Catalytic Cross-Coupling Reactions"
    ]
  ],
  "openalex": "W7203680948",
  "pdf_url": "https://www.nature.com/articles/s41557-026-02231-5.pdf",
  "pmcid": "PMC13652010",
  "pmid": "42613450",
  "published": "2026-08-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9snbe3pffg3fn.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:23:13Z",
      "native_id": "PMC13652010",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41557-026-02231-5"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic Cross-Coupling Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Regiospecific α-arylation of diverse carbonyl compounds using an organobismuth transporter",
  "title_text": "Regiospecific α-arylation of diverse carbonyl compounds using an organobismuth transporter",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:23:13Z",
  "url": "https://research.draconitic.com/paper/9snbe3pffg3fn",
  "venue": "Nature Chemistry",
  "versions": []
}