{
  "abstract": "Objective: To investigate the association between the apolipoprotein B to apolipoprotein A (ApoB/ApoA) ratio and sudden sensorineural hearing loss (SSNHL) risk in Nantong, China.\n\nMethods: This cross-sectional study included 1211 participants (674 with normal hearing, 537 with SSNHL). Baseline demographics, comorbidities, and biochemical indicators were compared. Multivariable logistic regression evaluated the independent association between the ApoB/ApoA ratio and SSNHL risk. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were applied for sensitivity analysis. Stratified and dose-response analyses were also conducted.\n\nResults: The groups differed significantly in age, sex, hypertension, BMI, and various metabolic markers (all P < 0.05). In the fully adjusted model, an elevated ApoB/ApoA ratio was significantly associated with increased SSNHL risk (OR = 9.34, 95% CI: 3.93-22.21). This positive association remained robust after PSM (OR = 8.79, 95% CI: 3.26-23.66). IPTW analysis showed the high-ratio group (0.78-1.34) had a higher SSNHL risk than the low-ratio group (0.13-0.58) (OR = 2.28, 95% CI: 1.79-2.90). Dose-response analysis indicated a significant linear positive correlation between the ratio and SSNHL prevalence, both before and after PSM. Stratified analyses demonstrated this association remained consistent across age, sex, hypertension, and diabetes subgroups (all P for interaction > 0.05).\n\nConclusion: A high ApoB/ApoA ratio has a significant linear positive association with increased SSNHL risk. It serves as an independent clinical biomarker for SSNHL risk assessment, providing a basis for metabolic management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology, Tongzhou Branch of Nantong People’s Hospital (Nantong Tongzhou People’s Hospital)"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhisong Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Weilin Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoyang Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaodong Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9szr32q1q4dha.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1955992",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716602/?tool=EBI",
  "id": "9szr32q1q4dha",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1955992/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2808|Vestibular and auditory disorders"
    ]
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  "openalex": "W7222200496",
  "pdf_url": "https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1955992/pdf",
  "pmcid": "PMC13716602",
  "pmid": "42959176",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9szr32q1q4dha.ris",
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      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1955992/full"
    },
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13716602",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13716602"
    },
    {
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      "url": "https://europepmc.org/article/MED/42959176"
    },
    {
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      "native_id": "PMC13716602",
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      "url": "https://doi.org/10.3389/fendo.2026.1955992"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Vestibular and auditory disorders",
      "subfield": "neurology"
    }
  ],
  "title": "Elevated ApoB/ApoA ratio is associated with increased risk of sudden sensorineural hearing loss",
  "title_text": "Elevated ApoB/ApoA ratio is associated with increased risk of sudden sensorineural hearing loss",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:05Z",
  "url": "https://research.draconitic.com/paper/9szr32q1q4dha",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}