{
  "abstract": "Purpose: To evaluate whether pelvic lavage carcinoembryonic antigen (CEA) mRNA is associated with local recurrence after curative‐intent resection for rectal cancer and whether it provides additional prognostic information beyond circumferential resection margin (CRM) status.\n\nMethods: We retrospectively analyzed 178 patients who underwent curative‐intent resection for primary rectal cancer. Pelvic lavage fluid was collected intraoperatively before enterotomy, and CEA mRNA levels were quantified using quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR). CEA mRNA positivity was defined as ≥ 0.26, and CRM positivity as ≤ 1 mm. Local recurrence was evaluated using Kaplan–Meier analysis and Cox proportional hazards modeling.\n\nResults: During a median follow‐up of 59.1 months, local recurrence occurred in 8 patients (4.5%). CEA mRNA was positive in 7 patients (3.9%), and CRM was positive in 11 patients (6.2%). Local recurrence rates were 36.4% (4/11) in CRM‐positive patients and 42.9% (3/7) in CEA mRNA–positive patients. All patients who tested positive for both markers (3/3) developed local recurrence, whereas the rate was only 2.5% (4/163) among those who tested negative for both markers. In multivariable analysis, CRM positivity (HR 11.09, 95% CI 2.06–59.68, p = 0.005) and CEA mRNA positivity (HR 5.99, 95% CI 1.06–33.81, p = 0.043) remained associated with local recurrence.\n\nConclusions: Pelvic lavage CEA mRNA levels were associated with local recurrence beyond CRM status and may improve risk stratification. Further validation in larger multicenter cohorts is warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterological Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan",
    "Department of Gastroenterological Surgery Nagoya City University Hospital East Medical Center Nagoya Aichi Japan",
    "Department of Gastroenterological Surgery Nagoya City University Hospital West Medical Center Nagoya Aichi Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hiroyuki Asai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yushi Yamakawa"
    },
    {
      "affs": [
        1
      ],
      "name": "Kazuyoshi Shiga"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuhei Uehara"
    },
    {
      "affs": [
        0
      ],
      "name": "Akira Kato"
    },
    {
      "affs": [
        0
      ],
      "name": "Takuya Suzuki"
    },
    {
      "affs": [
        0
      ],
      "name": "Hajime Ushigome"
    },
    {
      "affs": [
        2
      ],
      "name": "Hiroki Takahashi"
    },
    {
      "affs": [
        1
      ],
      "name": "Yoichi Matsuo"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuji Takiguchi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9t6hw8czz9j3y.bib",
  "cited_by": 0,
  "doi": "10.1002/ags3.70257",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13426386/",
  "id": "9t6hw8czz9j3y",
  "issns": [
    "2475-0328"
  ],
  "landing_url": "https://doi.org/10.1002/ags3.70257",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2730|Colorectal Cancer Surgical Treatments"
    ]
  ],
  "openalex": "W7172019772",
  "pdf_url": null,
  "pmcid": "PMC13426386",
  "pmid": "42540612",
  "published": "2026-07-31",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/9t6hw8czz9j3y.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:23:27Z",
      "native_id": "PMC13426386",
      "source": "pmc",
      "url": "https://doi.org/10.1002/ags3.70257"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Colorectal Cancer Surgical Treatments",
      "subfield": "oncology"
    }
  ],
  "title": "Carcinoembryonic Antigen Messenger RNA in Pelvic Lavage Fluid Predicts Local Recurrence After Curative‐Intent Resection of Rectal Cancer",
  "title_text": "Carcinoembryonic Antigen Messenger RNA in Pelvic Lavage Fluid Predicts Local Recurrence After Curative‐Intent Resection of Rectal Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:56Z",
  "url": "https://research.draconitic.com/paper/9t6hw8czz9j3y",
  "venue": "Annals of Gastroenterological Surgery",
  "versions": []
}