{
  "abstract": "Introduction: The gut microbiota plays a vital role in porcine growth, intestinal barrier function, and disease resistance, yet the influence of host genetics on microbiota development and breed-specific phenotypes remains unclear. This study investigated gut microbiota dynamics in genetically distinct pig breeds and evaluated the functional impact of breed-specific microbiota on intestinal health.\n\nMethods: A total of 76 healthy 3-day-old piglets from Min pigs and Duroc × Landrace × Yorkshire (DLY) pigs were monitored from day 3 to day 49. Microbiota composition was analyzed at eight developmental stages using high-resolution 2bRAD-M sequencing. Intestinal tissues were collected at day 49 for spatial microbiota profiling and barrier function assessment. Additionally, twelve 21-day-old DLY piglets were assigned to control, Enterotoxigenic Escherichia coli (ETEC) K88 challenge, and fecal microbiota transplantation (FMT) groups to evaluate the protective effects of Min pig microbiota.\n\nResults: Significant breed-specific differences were observed in microbial composition, developmental trajectories, and ecological succession patterns. Min pigs exhibited higher microbial diversity and greater community stability during early weaning compared to DLY pigs, accompanied by improved intestinal barrier integrity and reduced diarrhea incidence. FMT from Min pigs significantly enhanced microbial diversity, strengthened intestinal barrier function, and alleviated diarrhea following ETEC challenge.\n\nDiscussion: These findings demonstrate that host genetics shapes gut microbiota development, influencing intestinal health and disease resistance. Microbiota derived from Min pigs confers protective effects against enteric infection, highlighting its potential as a microbial resource to improve gut health in commercial pig production.",
  "abstract_shown": true,
  "affiliations": [
    "College of Veterinary Medicine, Northeast Agricultural University",
    "Key Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University",
    "National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University",
    "Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Weichun Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhuoran Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinru Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Huitao Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaxuan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Wen Cui"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanping Jiang"
    },
    {
      "affs": [
        2
      ],
      "name": "Baifen Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaona Wang"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Lijie Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9t6nj3v43b4sm.bib",
  "cited_by": 0,
  "doi": "10.3389/fmicb.2026.1939230",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1939230/full",
  "id": "9t6nj3v43b4sm",
  "issns": [
    "1664-302X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1939230/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QR1-502"
    ],
    [
      "openalex",
      "1103|Animal Nutrition and Physiology"
    ]
  ],
  "openalex": "W7223677857",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9t6nj3v43b4sm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:12Z",
      "native_id": "10.3389/fmicb.2026.1939230",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1939230/full"
    },
    {
      "first_seen": "2026-10-30T13:47:17Z",
      "native_id": "03c06fe9437d452c980850cd97113f13",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fmicb.2026.1939230"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1103|Animal Nutrition and Physiology",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Gut microbiota developmental trajectories in min and DLY pigs during lactation and nursery stages and the alleviation of ETEC-induced diarrhea by fecal microbiota transplantation",
  "title_text": "Gut microbiota developmental trajectories in min and DLY pigs during lactation and nursery stages and the alleviation of ETEC-induced diarrhea by fecal microbiota transplantation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:21:07Z",
  "url": "https://research.draconitic.com/paper/9t6nj3v43b4sm",
  "venue": "Frontiers in Microbiology",
  "versions": []
}