{
  "abstract": "B‐cell maturation antigen‐directed chimeric antigen receptor (CAR) T cells have revolutionized the treatment of relapsed/refractory multiple myeloma. However, no randomized head‐to‐head comparison of idecabtagene vicleucel (ide‐cel) and ciltacabtagene autoleucel (cilta‐cel) is available, and real‐world data suggest differences in efficacy and toxicity. We performed a nationwide retrospective real‐world analysis (RWA) of Austrian patients treated with ide‐cel or cilta‐cel between January 2024 and July 2025. Ninety patients were included, with largely balanced baseline characteristics and frequent high‐risk features. Bridging therapy was administered to 94.4% of patients, resulting in high response rates prior to lymphodepletion. After a median follow‐up of 17.6 months, no early separation of the progression‐free survival (PFS) curves was observed between CAR‐T products. Multivariable analyses showed a trend towards improved PFS with cilta‐cel, whereas true extra‐medullary disease (EMD) and prior bispecific antibody treatment before T‐cell apheresis were associated with inferior PFS. Although previous RWA have demonstrated an early divergence in PFS between cilta‐cel and ide‐cel, this pattern was not observed in our cohort. The high effectiveness of bridging therapy may have contributed to these findings. Our results support further investigation of optimal bridging strategies and treatment sequencing while highlighting the persistent unmet need of patients with true EMD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine I: Hematology With Stem Cell Transplantation, Hemostaseology and Medical Oncology Ordensklinikum Linz Elisabethinen Linz Austria",
    "Medical Faculty Johannes Kepler University Linz Linz Austria",
    "Bone Marrow Transplantation Unit, Department of Medicine I Medical University of Vienna Vienna Austria",
    "Department of Internal Medicine III With Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology Paracelsus Medical University Salzburg Salzburg Austria",
    "Clinical Division of Hematology, Department of Internal Medicine Medical University of Graz Graz Austria",
    "Department of Internal Medicine V, Hematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) Medical University of Innsbruck Innsbruck Austria",
    "Department for Internal Medicine 1 University Hospital St Poelten – NOE LGA, Karl Landsteiner University St. Poelten Austria",
    "Department of Transfusion Medicine and Cell Therapy Medical University of Vienna Vienna Austria",
    "Division Hematology and Hemostaseology, Department of Medicine I Medical University of Vienna Vienna Austria"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Irene Strassl",
      "orcid": "0000-0001-9649-5850"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alexander Nikoloudis"
    },
    {
      "affs": [
        2
      ],
      "name": "Lina Zoe Ruesing",
      "orcid": "0009-0004-6008-029X"
    },
    {
      "affs": [
        3
      ],
      "name": "Thomas Melchardt",
      "orcid": "0000-0002-0122-3631"
    },
    {
      "affs": [
        3
      ],
      "name": "Michael Leisch"
    },
    {
      "affs": [
        4
      ],
      "name": "Eduard Schulz",
      "orcid": "0000-0002-6672-4592"
    },
    {
      "affs": [
        4
      ],
      "name": "Annkristin Heine"
    },
    {
      "affs": [
        4
      ],
      "name": "Peter Neumeister"
    },
    {
      "affs": [
        5
      ],
      "name": "Normann Steiner"
    },
    {
      "affs": [
        5
      ],
      "name": "Dominik Wolf"
    },
    {
      "affs": [
        5
      ],
      "name": "Wolfgang Willenbacher"
    },
    {
      "affs": [
        6
      ],
      "name": "Petra Pichler‐Izmir"
    },
    {
      "affs": [
        6
      ],
      "name": "Theresa Lentner"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Johannes Clausen",
      "orcid": "0000-0002-2729-9706"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Veronika Buxhofer‐Ausch",
      "orcid": "0000-0002-7369-9700"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sigrid Machherndl‐Spandl",
      "orcid": "0009-0007-1247-7948"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Olga Saini"
    },
    {
      "affs": [
        0
      ],
      "name": "Dagmar Wipplinger"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Holger Rumpold"
    },
    {
      "affs": [
        7
      ],
      "name": "Nina Worel",
      "orcid": "0000-0002-3599-8099"
    },
    {
      "affs": [
        2
      ],
      "name": "Werner Rabitsch"
    },
    {
      "affs": [
        2
      ],
      "name": "Axel Schulenburg"
    },
    {
      "affs": [
        8
      ],
      "name": "Hermine Agis",
      "orcid": "0000-0002-1125-0211"
    },
    {
      "affs": [
        8
      ],
      "name": "Maria‐Theresa Krauth"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9tbsv4verkp43.bib",
  "cited_by": 0,
  "doi": "10.1111/bjh.70773",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13748363/",
  "id": "9tbsv4verkp43",
  "issns": [
    "0007-1048",
    "1365-2141"
  ],
  "landing_url": "https://doi.org/10.1111/bjh.70773",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "ORIGINAL PAPER"
    ],
    [
      "heading",
      "Original Paper"
    ],
    [
      "heading",
      "Transplantation & Cellular Therapy"
    ],
    [
      "openalex",
      "2730|CAR-T cell therapy research"
    ]
  ],
  "openalex": "W7204270051",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.70773",
  "pmcid": "PMC13748363",
  "pmid": "42644320",
  "published": "2026-08-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9tbsv4verkp43.ris",
  "sources": [
    {
      "first_seen": "2026-11-13T12:26:13Z",
      "native_id": "PMC13748363",
      "source": "pmc",
      "url": "https://doi.org/10.1111/bjh.70773"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|CAR-T cell therapy research",
      "subfield": "oncology"
    }
  ],
  "title": "Real‐world outcomes of ide‐cel and cilta‐cel in relapsed/refractory multiple myeloma: A nationwide, retrospective analysis in Austria",
  "title_text": "Real‐world outcomes of ide‐cel and cilta‐cel in relapsed/refractory multiple myeloma: A nationwide, retrospective analysis in Austria",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:26:13Z",
  "url": "https://research.draconitic.com/paper/9tbsv4verkp43",
  "venue": "British Journal of Haematology",
  "versions": []
}