{
  "abstract": "Speech brain-computer interfaces (BCIs) can restore communication in individuals with neuromotor disorders who are unable to speak. However, current speech BCIs limit patient usability and successful deployment by requiring large volumes of patient-specific data collected over long periods of time. A promising solution to facilitate usability and accelerate their successful deployment is to combine data from multiple patients. This has proven difficult, however, due to differences in user neuroanatomy, varied placement of electrode arrays, and sparse sampling of targeted anatomy. Here, by aligning patient-specific neural data to a shared latent space, we show that speech BCIs can be trained on data combined across patients. Using canonical correlation analysis and high-density micro-electrocorticography (μECoG), we uncovered shared neural latent dynamics with preserved micro-scale speech information. This approach enabled cross-patient decoding models to achieve improved accuracies relative to patient-specific models facilitated by the high resolution and broad coverage of μECoG. Our findings support future speech BCIs that are more accurate and rapidly deployable, ultimately improving the quality of life for people with impaired communication from neuromotor disorders.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Engineering, Duke University, Durham, NC, USA",
    "Duke University",
    "McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA",
    "Department of Neurosurgery, Duke School of Medicine, Durham, NC, USA",
    "Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA",
    "University of Utah",
    "Department of Neurobiology, Duke School of Medicine, Durham, NC, USA",
    "Duke Comprehensive Epilepsy Center, Duke University, Durham, NC, USA",
    "Department of Biomedical Engineering, Duke University, Durham, NC, USA. j.viventi@duke.edu",
    "Department of Neurobiology, Duke School of Medicine, Durham, NC, USA. j.viventi@duke.edu",
    "Department of Neurosurgery, Duke School of Medicine, Durham, NC, USA. j.viventi@duke.edu",
    "Duke Comprehensive Epilepsy Center, Duke University, Durham, NC, USA. j.viventi@duke.edu",
    "Center for Cognitive Neuroscience, Duke University, Durham, NC, USA. gregory.cogan@duke.edu",
    "Department of Biomedical Engineering, Duke University, Durham, NC, USA. gregory.cogan@duke.edu",
    "Department of Neurology, Duke School of Medicine, Durham, NC, USA. gregory.cogan@duke.edu",
    "Department of Neurosurgery, Duke School of Medicine, Durham, NC, USA. gregory.cogan@duke.edu",
    "Duke Comprehensive Epilepsy Center, Duke University, Durham, NC, USA. gregory.cogan@duke.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Zachary Spalding",
      "orcid": "0009-0004-1769-7104"
    },
    {
      "affs": [
        0,
        2,
        1
      ],
      "name": "Suseendrakumar Duraivel",
      "orcid": "0000-0002-1110-1021"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Shervin Rahimpour",
      "orcid": "0000-0003-2718-181X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Charles Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Katrina J. Barth",
      "orcid": "0000-0002-0193-5057"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "C. Schmitz",
      "orcid": "0009-0003-7918-3080"
    },
    {
      "affs": [
        3,
        1
      ],
      "name": "Shivanand Pramod Lad",
      "orcid": "0000-0003-4991-5319"
    },
    {
      "affs": [
        3,
        1
      ],
      "name": "Allan H. Friedman"
    },
    {
      "affs": [
        6,
        3,
        7,
        1
      ],
      "name": "Derek G. Southwell",
      "orcid": "0000-0001-6465-3869"
    },
    {
      "affs": [
        8,
        9,
        10,
        11,
        1
      ],
      "name": "Jonathan Viventi",
      "orcid": "0000-0001-6054-0541"
    },
    {
      "affs": [
        12,
        13,
        14,
        15,
        16,
        1
      ],
      "name": "Gregory B. Cogan",
      "orcid": "0000-0003-1557-6507"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9thpb4p981nv8.bib",
  "cited_by": 6,
  "doi": "10.1038/s41467-026-75455-1",
  "fulltext_url": null,
  "id": "9thpb4p981nv8",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-75455-1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|EEG and Brain-Computer Interfaces"
    ]
  ],
  "openalex": "W4413425109",
  "pdf_url": null,
  "pmcid": "PMC12393509",
  "pmid": "40894619",
  "published": "2026-07-16",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/9thpb4p981nv8.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T13:20:56Z",
      "native_id": "W4413425109",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41467-026-75455-1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|EEG and Brain-Computer Interfaces",
      "subfield": "neuroscience"
    }
  ],
  "title": "Shared latent representations of speech production for cross-patient speech decoding",
  "title_text": "Shared latent representations of speech production for cross-patient speech decoding",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:49Z",
  "url": "https://research.draconitic.com/paper/9thpb4p981nv8",
  "venue": "Nature Communications",
  "versions": []
}