{
  "abstract": "Aim: Evidence guiding mechanical ventilation (MV) during CPR is limited, and device-calculated inspired tidal volume (VTi) during ongoing chest compressions may differ from the set volume during compressions. We compared VTi with protocolized MV and bag-valve ventilation (BVV) through an endotracheal tube for noninferiority.\n\nMethods: This single-center randomized crossover noninferiority trial enrolled 104 intubated adults meeting termination-of-resuscitation criteria without return of spontaneous circulation to receive BVV and MV in randomized order within a 5-min peri-termination window. Device-calculated VTi was recorded for 1 min per method during ongoing compressions. The primary outcome was the between-treatment difference in per-participant median VTi; the noninferiority margin was −150 mL (MV minus BVV).\n\nResults: Among 99 participants completing both periods, mean per-participant median VTi was 514.4 mL with BVV and 368.0 mL with MV; coefficients of variation were 40.1% and 28.3%. The adjusted mean difference was −146.2 mL (95% CI, −187.0 to −105.5). Because the lower bound crossed −150 mL, noninferiority was not demonstrated. Median VTi exceeded 10 mL/kg predicted body weight in 31.3% with BVV and 0% with MV, whereas values below 6 mL/kg occurred in 26.3% and 45.5%.\n\nConclusions: Protocolized MV produced lower and less variable device-calculated VTi than BVV but did not meet noninferiority. BVV had a wider upper tail, whereas MV more often produced values below 6 mL/kg. The unvalidated analyzer and absence of clinical outcomes limit interpretation.\n\nClinical trial registration: Clinical Trials Registry − India; CTRI/2024/08/072738.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Emergency Medicine and Trauma, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantari Nagar, Puducherry 605006, India"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "S. Vinay"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Manu Ayyan"
    },
    {
      "affs": [
        0
      ],
      "name": "V.T. Amrithanand"
    },
    {
      "affs": [
        0
      ],
      "name": "B.G. Kowsthubha"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9tjyf2khx0c9q.bib",
  "cited_by": 0,
  "doi": "10.1016/j.resplu.2026.101530",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733466/",
  "id": "9tjyf2khx0c9q",
  "issns": [
    "2666-5204"
  ],
  "landing_url": "https://doi.org/10.1016/j.resplu.2026.101530",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2711|Cardiac Arrest and Resuscitation"
    ]
  ],
  "openalex": "W7221700329",
  "pdf_url": null,
  "pmcid": "PMC13733466",
  "pmid": "42985663",
  "published": "2026-10-13",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/9tjyf2khx0c9q.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:14Z",
      "native_id": "PMC13733466",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.resplu.2026.101530"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2711|Cardiac Arrest and Resuscitation",
      "subfield": "general"
    }
  ],
  "title": "Mechanical ventilation vs bag-valve ventilation during cardiopulmonary resuscitation: a randomized crossover noninferiority trial",
  "title_text": "Mechanical ventilation vs bag-valve ventilation during cardiopulmonary resuscitation: a randomized crossover noninferiority trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:14Z",
  "url": "https://research.draconitic.com/paper/9tjyf2khx0c9q",
  "venue": "Resuscitation Plus",
  "versions": []
}