{
  "abstract": "Tumor-infiltrating tissue-resident memory (TRM)-like CD8+ T cells correlate with positive prognosis and better responses to cancer immunotherapy, yet the mechanisms underlying their specification remain ill-understood. Here, we use the KP (KrasG12D, p53-/-) mouse model of lung adenocarcinoma to investigate how different dendritic cell (DC) subsets shape tumor-specific CD8+ T cell responses. Selective ablation of XCR1+ DC1s or IRF4-dependent CD11b+ DC2s reveal that DC1s, but not DC2s, are required for the generation of tumor-infiltrating effector and exhausted CD8+ T cells. By contrast, both migratory DC1s and migratory DC2s contribute to the specification of CD103+CD69+ TRM-like CD8+ T cells in tumor-draining lymph nodes. Mechanistically, low peptide/MHC-I density on migratory DC2s favors TGFβ-dependent TRM differentiation, while high peptide/MHC-I density on DC1s promote proliferative expansion of TRM-like cells; in addition, IL-12 secreted by DC1s enhances CXCR6 expression. Together, our findings uncover complementary functions of migratory DC subsets in shaping anti-tumor TRM-like CD8+ T cell responses, and also implicate targeting multiple DC subsets for optimizing cancer immunotherapy.",
  "abstract_shown": true,
  "affiliations": [
    "\"Dendritic Cells and Adaptive Immunity\" Unit, Immunology Department, Institut Pasteur, Paris, France.",
    "CNRS UMR3738 \"Developmental Biology and Stem Cells\", Institut Pasteur, Paris, France.",
    "Center for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.",
    "INSERM UMR1149, CNRS EMR8252, Centre de Recherche sur l'Inflammation, Faculté de Médecine site Bichat, Université Paris Cité, Paris, France.",
    "Phagocytes and Cancer Immunology laboratory, INSERM U1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France.",
    "Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium.",
    "Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.",
    "Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK.",
    "Dynamics of Immune Responses Unit, INSERM U1223, Institut Pasteur, Université Paris Cité, Paris, France.",
    "U1356 Next Generation Immuno-Oncology Research, Gustave Roussy, Université Paris-Saclay, Villejuif, France.",
    "Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.",
    "CNRS UMR9018 Cancer biology and metabolism, Gustave Roussy, Université Paris-Saclay, Villejuif, France.",
    "Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.",
    "Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.",
    "Immunology-Immunopathology-Immunotherapy (i3), UMRS 959, INSERM, Sorbonne Université, Paris, France.",
    "Faculté de Médecine, Université Paris Cité, Paris, France.",
    "Nutrition and Obesity: Systemic Approaches, Inserm, Sorbonne University, Paris, France.",
    "Turing Center for Living Systems, Centre d'Immunologie de Marseille-Luminy, CNRS, INSERM, CIML, Aix-Marseille University, Marseille, France.",
    "INSERM U970, PARCC, Université de Paris Cité, Paris, France.",
    "Physiology and Cancer Research Programme, Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.",
    "Barts Cancer Institute, Queen Mary University of London, London, UK.",
    "International Centre for Genome Engineering and Biotechnology, Trieste, Italy.",
    "\"Dendritic Cells and Adaptive Immunity\" Unit, Immunology Department, Institut Pasteur, Paris, France. pierre.guermonprez@pasteur.fr.",
    "CNRS UMR3738 \"Developmental Biology and Stem Cells\", Institut Pasteur, Paris, France. pierre.guermonprez@pasteur.fr.",
    "Center for Vaccine and Immunotherapy, Institut Pasteur, Paris, France. pierre.guermonprez@pasteur.fr."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 36,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Nathan Vaudiau",
      "orcid": "0000-0001-9586-8467"
    },
    {
      "affs": [
        3,
        4,
        5,
        6
      ],
      "name": "Pierre Bourdely",
      "orcid": "0000-0002-4162-1490"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Maria Semitekolou"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Agathe Ok",
      "orcid": "0009-0005-9883-5288"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Louise Gorline",
      "orcid": "0009-0008-8499-9603"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Aboubacar Sidiki K Coulibaly",
      "orcid": "0000-0002-2043-8806"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Matthieu Rastello"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Aurélie Semervil"
    },
    {
      "affs": [
        7
      ],
      "name": "Roberto Savoldelli",
      "orcid": "0000-0002-4524-9243"
    },
    {
      "affs": [
        4
      ],
      "name": "Yohan Gerber-Ferder",
      "orcid": "0000-0001-9973-2196"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Fillipe Luiz Rosa do Carmo",
      "orcid": "0000-0003-4405-1013"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Mathias Vétillard"
    },
    {
      "affs": [
        3
      ],
      "name": "Audrey Rood"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jérémie Bornères"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Abdenour Abbas",
      "orcid": "0000-0003-2372-4530"
    },
    {
      "affs": [
        4
      ],
      "name": "Marie Guillin",
      "orcid": "0009-0007-6344-5030"
    },
    {
      "affs": [
        4
      ],
      "name": "Judith Weber",
      "orcid": "0009-0001-5349-162X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Syrine Bouallegue"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Konstantina Pamboukas"
    },
    {
      "affs": [
        8
      ],
      "name": "Zacarias Garcia"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Florent Ginhoux",
      "orcid": "0000-0002-2857-7755"
    },
    {
      "affs": [
        11
      ],
      "name": "Camille Blériot"
    },
    {
      "affs": [
        8
      ],
      "name": "Philippe Bousso"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Yosuke Kumamoto",
      "orcid": "0000-0001-9369-4934"
    },
    {
      "affs": [
        14,
        15
      ],
      "name": "Guillaume Darrasse-Jèze",
      "orcid": "0000-0003-3069-8211"
    },
    {
      "affs": [
        16
      ],
      "name": "Emmanuel L Gautier",
      "orcid": "0000-0003-2976-7566"
    },
    {
      "affs": [
        17
      ],
      "name": "Marc Dalod",
      "orcid": "0000-0002-6436-7966"
    },
    {
      "affs": [
        18
      ],
      "name": "Eric Tartour",
      "orcid": "0000-0002-7323-468X"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Tessa Bergsbaken",
      "orcid": "0000-0001-8841-8185"
    },
    {
      "affs": [
        19
      ],
      "name": "Klaas P J M Van Gisbergen",
      "orcid": "0000-0003-3623-7555"
    },
    {
      "affs": [
        20
      ],
      "name": "Kairbaan M Hodivala-Dilke",
      "orcid": "0000-0002-2859-749X"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Massimiliano Mazzone",
      "orcid": "0000-0001-8824-4015"
    },
    {
      "affs": [
        3
      ],
      "name": "Loredana Saveanu",
      "orcid": "0000-0003-3138-7968"
    },
    {
      "affs": [
        4
      ],
      "name": "Julie Helft",
      "orcid": "0000-0002-2733-1972"
    },
    {
      "affs": [
        21
      ],
      "name": "Federica Benvenuti",
      "orcid": "0000-0002-1908-8052"
    },
    {
      "affs": [
        22,
        23,
        24
      ],
      "name": "Pierre Guermonprez",
      "orcid": "0000-0001-5621-2262"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9tt4gxq93aa2b.bib",
  "cited_by": 1,
  "doi": "10.1038/s41467-026-77641-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13680476",
  "id": "9tt4gxq93aa2b",
  "issns": [
    "2041-1723",
    "2041-1723"
  ],
  "landing_url": "https://hal.science/hal-05762918v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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    [
      "openalex",
      "2403|Immunotherapy and Immune Responses"
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  "pdf_url": "https://hal.science/hal-05762918/document",
  "pmcid": "PMC13680476",
  "pmid": "42897144",
  "published": "2026-09-18",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/9tt4gxq93aa2b.ris",
  "sources": [
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      "first_seen": "2026-10-30T12:17:41Z",
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      "native_id": "MED:42897144",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897144"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immunotherapy and Immune Responses",
      "subfield": "immunology"
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  ],
  "title": "Distinct migratory dendritic cell subsets cooperate to prime tissue-resident memory-like CD8⁺ T cells in mouse tumors",
  "title_text": "Distinct migratory dendritic cell subsets cooperate to prime tissue-resident memory-like CD8⁺ T cells in mouse tumors",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/9tt4gxq93aa2b",
  "venue": "Nature Communications",
  "versions": []
}