{
  "abstract": "The extract of Acmella oleracea L. (jambu) contains significant amounts of spilanthol and phenolic compounds, which have wide-ranging applications in the cosmetic and pharmaceutical industries. The objective of this study was to optimize ultrasound-assisted extraction (UAE) of hydroethanolic extracts from A. oleracea L. using a Box–Behnken factorial design combined with response surface methodology and to directly compare the results with those of the conventional percolation method. The effects of the ethanol-to-water ratio, extraction time, and solid-to-solvent ratio were evaluated on yield, total phenolic content, total flavonoid content, and antioxidant activity. In addition, Fourier-transform infrared (FT-IR) spectroscopy was used for chemical characterization and extraction monitoring. For UAE, the optimal conditions established were an ethanol/water ratio of 47:53 (v/v), an extraction time of 13.2 min, and a solid-to-solvent ratio of 1:10 (m/v). In contrast, optimal percolation yielded an 11.03% recovery using a 70:30 (v/v) ethanol/water ratio. UAE provided a significantly higher yield (17.61%) and better recovery of bioactive compounds, as well as superior antioxidant activity in all assays. FT-IR analysis confirmed the preservation of functional groups, demonstrating that UAE optimizes the recovery of oxygen-containing compounds. It is concluded that UAE is a green, rapid, and sustainable alternative that maximizes the potential of A. oleracea L. for future cosmetic and nutritional formulations.",
  "abstract_shown": true,
  "affiliations": [
    "Federal University of Pará , , , ,",
    "Marajó-Breves University Campus, Federal University of Pará , , , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Robert C. S. P. dos Santos"
    },
    {
      "affs": [
        0
      ],
      "name": "Taís V. G. Alves"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana Carolina G. A. Freitas"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana Marla D. Souza"
    },
    {
      "affs": [
        1
      ],
      "name": "Manolo Cleiton C. Freitas"
    },
    {
      "affs": [
        0
      ],
      "name": "Camilo B. Teixeira"
    },
    {
      "affs": [
        0
      ],
      "name": "Roseane M. Ribeiro-Costa",
      "orcid": "0000-0001-5470-0617"
    },
    {
      "affs": [
        0
      ],
      "name": "José Otávio C. Silva-Júnior",
      "orcid": "0000-0003-1691-1039"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9v12yr1r9ywcc.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c01930",
  "fulltext_url": null,
  "id": "9v12yr1r9ywcc",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c01930/5466274/Ultrasound-Assisted-Extraction-of-Bioactive",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": "https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c01930/69114623/acsomega.6c01930.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-08",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/9v12yr1r9ywcc.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T00:20:50Z",
      "native_id": "10.1021/acsomega.6c01930",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c01930/5466274/Ultrasound-Assisted-Extraction-of-Bioactive"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:2470-1343",
      "subfield": "general"
    }
  ],
  "title": "Ultrasound-Assisted Extraction of Bioactive Compounds from Acmella oleracea L. Leaves: Optimization by Response Surface Methodology and Comparison with Percolation",
  "title_text": "Ultrasound-Assisted Extraction of Bioactive Compounds from Acmella oleracea L. Leaves: Optimization by Response Surface Methodology and Comparison with Percolation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:10Z",
  "url": "https://research.draconitic.com/paper/9v12yr1r9ywcc",
  "venue": "ACS Omega",
  "versions": []
}