{
  "abstract": "Background\n\nSurgical resection is the primary treatment for solid pseudopapillary neoplasms (SPN). Systemic treatment options are limited; no prospective trials or consensus guidelines exist given the rarity of SPN.Patients and methods\n\nWe retrospectively reviewed patients treated for SPN at Memorial Sloan Kettering Cancer Center from 2009-2024, summarizing demographics, treatments, outcomes, and genetic testing results when available.Results\n\nOf 45 patients, 42 (93%) underwent surgical resection and 8 (18%) received systemic or locoregional treatment (average 3.25 therapies per patient). Genetic testing was available for 10 patients (22%), 9 of whom had Wnt/β-catenin pathway alterations. One patient whose tumor harbored a CTNNB1 mutation was treated with an investigational therapy inhibiting β-catenin, achieving disease control for 7 months.Conclusion\n\nThis is the largest single-institution series of treatment of advanced SPN, demonstrating that select therapies can provide disease control. Molecular characterization of SPN frequently identifies Wnt/β-catenin pathway alterations, demonstrating a potential clinical benefit for drugs targeting this pathway.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastrointestinal Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States.",
    "Division of Medical Oncology, Duke Cancer Institute, Durham, NC 27710, United States."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Courtney Porfido",
      "orcid": "0009-0000-2116-5515"
    },
    {
      "affs": [
        1
      ],
      "name": "Diane Reidy-Lagunes"
    },
    {
      "affs": [
        0
      ],
      "name": "Nitya Raj"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9v9vt5nshq9ks.bib",
  "cited_by": 0,
  "doi": "10.1093/oncolo/oyag393",
  "fulltext_url": "https://europepmc.org/articles/PMC13680103",
  "id": "9v9vt5nshq9ks",
  "issns": [
    "1083-7159",
    "1549-490X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42841746",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W7220848813",
  "pdf_url": "https://europepmc.org/articles/PMC13680103?pdf=render",
  "pmcid": "PMC13680103",
  "pmid": "42841746",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9v9vt5nshq9ks.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42841746",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42841746"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Pancreatic and Hepatic Oncology Research",
      "subfield": "oncology"
    }
  ],
  "title": "Treatment of metastatic solid pseudopapillary neoplasms.",
  "title_text": "Treatment of metastatic solid pseudopapillary neoplasms.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/9v9vt5nshq9ks",
  "venue": "The oncologist",
  "versions": []
}