{
  "abstract": "Meropenem is a valuable option for outpatient parenteral antimicrobial therapy (OPAT) due to its broad-spectrum activity, including multidrug-resistant Gram-negative bacteria, particularly when no oral alternatives exist. However, its conventional thrice-daily dosing poses logistical challenges for home administration, as the third dose typically falls during nighttime. This prospective pharmacokinetic study evaluated the adequacy of a novel daytime-only meropenem regimen adapted for OPAT in non-critically ill hospitalized patients. Twenty-two patients receiving meropenem 2 g every 8 h were switched, once clinically stable, to a thrice-daily, 6-hourly regimen compatible with daytime administration only. Meropenem was infused over 20 min. At steady state, unbound meropenem concentrations were measured for both regimens. These data informed a population pharmacokinetic model and Monte Carlo simulations to compare the probability of achieving predefined PK/PD targets. Both the conventional and OPAT-adapted regimens achieved a probability of target attainment (PTA) >90% for 40% f T >MIC at MIC ≤4 mg/L, exceeding the EUCAST/IDSA susceptibility breakpoint of 2 mg/L. Extending the infusion duration to 3 or 5 h with the OPAT-adapted schedule restored PTA >90% for MIC ≤8 mg/L. However, trough concentrations after the evening dose were lower with the OPAT-adapted regimen than with the standard regimen (1–2 vs 3–5 mg/L, depending on infusion duration). This may increase the risk of resistance selection despite the post-antibiotic effect of meropenem. With this caveat, OPAT regimens, with infusion duration adapted to MIC, may enable practical daytime-only meropenem administration, avoiding the need for overnight nursing visits.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Caroline Briquet"
    },
    {
      "name": "Perrin Ngougni Pokem"
    },
    {
      "name": "Xin Liu"
    },
    {
      "name": "Gert-Jan Wijnant"
    },
    {
      "name": "Olivier Cornu"
    },
    {
      "name": "Halil Yildiz"
    },
    {
      "name": "Alexia Verroken"
    },
    {
      "name": "Jason A. Roberts"
    },
    {
      "name": "Jean Cyr Yombi"
    },
    {
      "name": "Françoise van Bambeke"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9vbrep01sy3p1.bib",
  "cited_by": 0,
  "doi": "10.1128/aac.00372-26",
  "fulltext_url": null,
  "id": "9vbrep01sy3p1",
  "issns": [
    "0066-4804",
    "1098-6596"
  ],
  "landing_url": "https://hal.science/hal-05799941v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "openalex",
      "2736|Antibiotics Pharmacokinetics and Efficacy"
    ]
  ],
  "openalex": "W7164576455",
  "pdf_url": "https://hal.science/hal-05799941/document",
  "pmcid": null,
  "pmid": "42283568",
  "published": "2026-06-12",
  "publisher": "American Society for Microbiology",
  "ris": "https://research.draconitic.com/paper/9vbrep01sy3p1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "hal-05799941",
      "source": "hal",
      "url": "https://hal.science/hal-05799941v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Antibiotics Pharmacokinetics and Efficacy",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "A novel meropenem dosing strategy for Outpatient Parenteral Antimicrobial Therapy (OPAT): a pilot pharmacokinetic/pharmacodynamic study in non-critically ill patients",
  "title_text": "A novel meropenem dosing strategy for Outpatient Parenteral Antimicrobial Therapy (OPAT): a pilot pharmacokinetic/pharmacodynamic study in non-critically ill patients",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/9vbrep01sy3p1",
  "venue": "Antimicrobial Agents and Chemotherapy",
  "versions": []
}