{
  "abstract": "Aims: To evaluate 6-month effects of a multi-ingredient nutritional powder formulation targeting complementary pathways relevant to vascular ageing on endothelial function and other vascular ageing markers in apparently healthy adults.\n\nMethods and results: The effects of a supplement to target ageing mechanisms on vascular function study was a double-blind, randomized, controlled trial. Participants received a multi-ingredient nutritional powder formulation comprising vitamins/minerals, amino acids, and plant-derived bioactives, or control for 6 months. Vascular assessments were performed at baseline and after 6 months (with an acute post-dose assessment). The primary outcome was change in brachial artery flow-mediated dilation (FMD). Secondary outcomes included pulse wave velocity (PWV), peripheral and central blood pressure, augmentation index, lipid profile, and estimated 10-year cardiovascular risk (SCORE2/SCORE2-OP). Sixty-one participants (baseline SCORE2/SCORE2-OP 3.6 ± 2.9%) were randomized (33 actives; 28 controls); 43 completed both visits (24 vs. 19). Compared with control, the supplement improved endothelial function (ΔΔFMD at 6 months +2.9% [95% CI 2.1–3.8]) and reduced arterial stiffness (ΔΔPWV −1.18 m/s [95% CI −2.00 to −0.36]). Peripheral systolic blood pressure (SBP) decreased (ΔΔSBP −6.1 mmHg [95% CI −10.9 to −1.3]). Lipids were unchanged. Estimated 10-year cardiovascular risk decreased (ΔΔSCORE2/SCORE2-OP −0.45% [95% CI −0.86 to −0.03]).\n\nConclusion: Daily intake of a multi-ingredient nutritional powder formulation was associated with sustained improvements in endothelial function, arterial stiffness, and systolic blood pressure, with a modest reduction in estimated 10-year cardiovascular risk primarily attributable to lower systolic blood pressure rather than lipid change.\n\nRegistration: clinicaltrials.gov NCT06145087.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Charles Piercy",
      "orcid": "0000-0003-2942-7617"
    },
    {
      "name": "Jenny Harris",
      "orcid": "0000-0001-8933-117X"
    },
    {
      "name": "Kenza Sackho"
    },
    {
      "name": "Paola Campagnolo",
      "orcid": "0000-0002-8957-3969"
    },
    {
      "name": "Diogo Barardo",
      "orcid": "0000-0001-6177-0728"
    },
    {
      "name": "Ben Creagh-Brown",
      "orcid": "0000-0002-4397-1232"
    },
    {
      "name": "Christian Heiss",
      "orcid": "0000-0002-3212-8995"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9vfrfkt9k0jex.bib",
  "cited_by": 0,
  "doi": "10.1093/ehjopen/oeag157",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730552/?tool=EBI",
  "id": "9vfrfkt9k0jex",
  "issns": [
    "2752-4191"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13730552",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00200"
    ],
    [
      "heading",
      "Epidemiology and Prevention"
    ],
    [
      "heading",
      "Eurheartj/30"
    ],
    [
      "heading",
      "Eurheartj/45"
    ],
    [
      "heading",
      "Eurheartj/47"
    ],
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2705|Cardiovascular Health and Disease Prevention"
    ]
  ],
  "openalex": "W7214611191",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730552/pdf/?tool=EBI",
  "pmcid": "PMC13730552",
  "pmid": "42979377",
  "published": "2026-11-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/9vfrfkt9k0jex.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13730552",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13730552"
    },
    {
      "first_seen": "2026-11-07T12:23:05Z",
      "native_id": "PMC13730552",
      "source": "pmc",
      "url": "https://doi.org/10.1093/ehjopen/oeag157"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Health and Disease Prevention",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Acute and 6-month vascular effects of a multi-component nutritional supplement: a randomized controlled trial",
  "title_text": "Acute and 6-month vascular effects of a multi-component nutritional supplement: a randomized controlled trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:05Z",
  "url": "https://research.draconitic.com/paper/9vfrfkt9k0jex",
  "venue": "European heart journal open",
  "versions": []
}