{
  "abstract": "Gut microbial dysbiosis is common in inflammatory bowel disease (IBD), but whether specific taxa are causal, and through which host genes, remains unclear. We integrated two-sample Mendelian randomization (MR), replication, cis-eQTL colocalization, and single-cell mapping to identify microbial taxa with genetically predicted associations and candidate host mediators. Instruments for 211 taxa from MiBioGen (p < 1×10⁻⁵, r² < 0.001) were used in two-sample MR (inverse-variance weighted IVW primary; sensitivity: Egger, weighted median, MR-PRESSO) against IBD, Crohn's disease (CD), and ulcerative colitis (UC) in the International IBD Genetics Consortium (IIBDGC), with false discovery rate (FDR) correction. Replication was conducted in FinnGen R12; gene prioritization was performed via cis-SMR/coloc.abf using GTEx v8/CAGE eQTLs, and localization in 11,175 colonic cells. MR identified 15 significant associations (FDR < 0.05) across eight features; applying a pre-specified heterogeneity-based rule, 13 across seven independent features were retained as primary associations (strongest NB1n → CD, OR 1.32) and two were downgraded to suggestive; at the independent-signal level, three of 11 associations were replicated and seven were direction-concordant in FinnGen. Colocalization supported shared variants at SENP7 (blood, CD PP.H4 = 0.86, IBD = 0.70) and ZBTB11-AS1 (colon, IBD = 0.76, CD = 0.74); single-cell analysis mapped SENP7 to T/NK, and ZBTB11-AS1/VIPR1 to epithelial/goblet. Replicated MR and colocalization prioritized SENP7 (whole-blood eQTL; minor T/NK-cell detection) and ZBTB11-AS1 (colon epithelium) as candidate effectors, though the latter lacks functional characterization.",
  "abstract_shown": true,
  "affiliations": [
    "School of Medicine, Guangxi University, No. 100 Daxue East Road, Nanning 530004, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qiyuan Zou",
      "orcid": "0000-0001-9497-847X"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianyi Wang",
      "orcid": "0000-0003-3917-8327"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9vfzmk82w93hs.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198718",
  "fulltext_url": "https://europepmc.org/articles/PMC13665393",
  "id": "9vfzmk82w93hs",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883969",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7214762192",
  "pdf_url": "https://europepmc.org/articles/PMC13665393?pdf=render",
  "pmcid": "PMC13665393",
  "pmid": "42883969",
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9vfzmk82w93hs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883969",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883969"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Gut Microbiota, Inflammatory Bowel Disease and the Prioritization of Host Effector Genes: A Two-Sample Mendelian Randomization Study with Independent Replication, cis-eQTL Colocalization and Single-Cell Localization.",
  "title_text": "Gut Microbiota, Inflammatory Bowel Disease and the Prioritization of Host Effector Genes: A Two-Sample Mendelian Randomization Study with Independent Replication, cis-eQTL Colocalization and Single-Cell Localization.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/9vfzmk82w93hs",
  "venue": "International journal of molecular sciences",
  "versions": []
}