{
  "abstract": "Plant specialized metabolites play important roles in plant–microbe interactions. Beyond direct antimicrobial activity, some can attenuate pathogen virulence without markedly inhibiting microbial growth. Many gram-negative phytopathogenic bacteria cause important crop diseases and possess interconnected virulence systems, providing multiple opportunities for intervention by plant-derived anti-virulence metabolites. In this review, we summarize recent advances in these metabolites against gram-negative phytopathogenic bacteria according to three functional levels: virulence signal decision-making, virulence execution, and pathogenic ecological phenotypes. Particular attention is given to the strength of mechanistic evidence, including target engagement, pathway modulation, and disease-related outcomes. We further interpret these activities in the chemical-ecology context of plant–pathogen interactions and discuss the challenges and prospects of developing plant-derived metabolites as anti-virulence agents.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Microbiology, Hunan Academy of Agricultural Sciences, Changsha 410125, China",
    "Hunan Province Engineering Research Center for Agricultural Microbiology Application, Hunan Institute of Microbiology, Changsha 410009, China",
    "National Collection of Plant-Associated Microbes (Hunan), Changsha 410009, China",
    "Changsha Technology Innovation Center for Exploration and Utilization of Agricultural Microbial Germplasm Resources, Changsha 410009, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ying Tang",
      "orcid": "0000-0003-0378-9150"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xuning Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Cuiyang Zhang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Binbin Huang",
      "orcid": "0000-0002-5587-8553"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ye Li"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Zhaohui Guo"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Qingshu Liu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Liyang Wu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jie Du"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9w61s2r9kzznk.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16100768",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706779/?tool=EBI",
  "id": "9w61s2r9kzznk",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://www.mdpi.com/2218-1989/16/10/768",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Plant Pathogenic Bacteria Studies"
    ]
  ],
  "openalex": "W7221532386",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706779/pdf/?tool=EBI",
  "pmcid": "PMC13706779",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/9w61s2r9kzznk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "10.3390/metabo16100768",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-1989/16/10/768"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13706779",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706779"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Pathogenic Bacteria Studies",
      "subfield": "plant-biology"
    }
  ],
  "title": "Plant-Derived Anti-Virulence Metabolites Targeting Gram-Negative Phytopathogens: Recent Advances and Perspectives",
  "title_text": "Plant-Derived Anti-Virulence Metabolites Targeting Gram-Negative Phytopathogens: Recent Advances and Perspectives",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:40Z",
  "url": "https://research.draconitic.com/paper/9w61s2r9kzznk",
  "venue": "Metabolites",
  "versions": []
}