{
  "abstract": "Over the last decade it has become clear that obesity and type 2 diabetes are key to the aetiology, pathogenesis and outcomes of metabolic dysfunction-associated steatotic liver disease (MASLD). The considerable current and potential burden of MASLD on patients and healthcare systems is therefore inextricably linked with today's global epidemics of obesity and type 2 diabetes. In this review, we discuss estimates of the global MASLD burden in terms of prevalence, incidence, disability from complications and reduced life expectancy associated with the condition. We also highlight the variability in MASLD prevalence estimates among different populations, with a particular focus on the sub-Saharan Africa and Asia Pacific regions, where population increases and the epidemiological transition (a sustained shift in population mortality and disease patterns from infectious diseases towards non-communicable diseases) are occurring most rapidly. Additionally, we consider the impact of social determinants of health, including socioeconomic conditions, structural inequities, care access, food environments and systemic discrimination. We also identify opportunities to advance equity in MASLD prevention, diagnosis and treatment worldwide.",
  "abstract_shown": true,
  "affiliations": [
    "Usher Institute of Population Health Sciences, University of Edinburgh, Edinburgh, UK. sarah.wild@ed.ac.uk",
    "Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain",
    "City University of New York Graduate School of Public Health and Health Policy (CUNY SPH), New York, NY, USA",
    "Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain",
    "Division of Hepatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa",
    "Makerere University College of Health Sciences, Kampala, Uganda",
    "National Institute for Health and Care Research, Southampton Biomedical Research Centre, University Hospital Southampton and University of Southampton, Southampton, UK",
    "Wenzhou Medical University, Zhejiang, China",
    "National Institute for Health and Care Research, Southampton Biomedical Research Centre, University Hospital Southampton and University of Southampton, Southampton, UK. c.d.byrne@soton.ac.uk"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sarah H. Wild",
      "orcid": "0000-0001-7824-2569"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Jeffrey Victor Lazarus",
      "orcid": "0000-0001-9618-2299"
    },
    {
      "affs": [
        4
      ],
      "name": "C Wendy Spearman",
      "orcid": "0000-0003-3199-301X"
    },
    {
      "affs": [
        5
      ],
      "name": "Ponsiano Ocama",
      "orcid": "0000-0002-6120-1055"
    },
    {
      "affs": [
        6
      ],
      "name": "Josh Bilson",
      "orcid": "0000-0003-4665-3886"
    },
    {
      "affs": [
        7
      ],
      "name": "Xiaodong Zhou",
      "orcid": "0000-0002-8534-0818"
    },
    {
      "affs": [
        7
      ],
      "name": "Ming‐Hua Zheng",
      "orcid": "0000-0003-4984-2631"
    },
    {
      "affs": [
        8
      ],
      "name": "Christopher D. Byrne",
      "orcid": "0000-0001-6322-7753"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9wjn6m463f150.bib",
  "cited_by": 11,
  "doi": "10.1007/s00125-026-06726-1",
  "fulltext_url": null,
  "id": "9wjn6m463f150",
  "issns": [
    "0012-186X",
    "1432-0428"
  ],
  "landing_url": "https://doi.org/10.1007/s00125-026-06726-1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
    ],
    [
      "openalex",
      "2721|Liver Disease Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7162002918",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00125-026-06726-1.pdf",
  "pmcid": "PMC13627207",
  "pmid": "42168648",
  "published": "2026-05-21",
  "publisher": "Springer Science+Business Media",
  "ris": "https://research.draconitic.com/paper/9wjn6m463f150.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T13:20:46Z",
      "native_id": "W7162002918",
      "source": "openalex",
      "url": "https://doi.org/10.1007/s00125-026-06726-1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "MASLD prevalence, incidence and global aspects",
  "title_text": "MASLD prevalence, incidence and global aspects",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:51Z",
  "url": "https://research.draconitic.com/paper/9wjn6m463f150",
  "venue": "Diabetologia",
  "versions": []
}