{
  "abstract": "One prominent open question in the field of antisense oligonucleotide remains the intracellular delivery of active sequences. While different strategies have been developed for addressing this issue, including formulation and/or conjugation approaches, multiconjugations with both sugars and nucleolipids have not been investigated so far. In this contribution, we are interested in a new hypothesis that focuses on the double conjugation of oligonucleotides with both glucose-thymine and nucleolipid moieties. The lipid carbohydrate modified antisense oligonucleotides were the most efficient in down regulating the expression of KRAS in pancreatic cancer cells.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Faith Kivunga"
    },
    {
      "name": "Julien Verget"
    },
    {
      "name": "Helene Pereira"
    },
    {
      "name": "Brune Vialet"
    },
    {
      "name": "Patricia Korczak"
    },
    {
      "name": "Virginie Baylot"
    },
    {
      "name": "Jean Dessolin"
    },
    {
      "name": "Philippe Barthélémy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9x7qvkxr3y6cx.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.bioconjchem.5c00627",
  "fulltext_url": null,
  "id": "9x7qvkxr3y6cx",
  "issns": [
    "1043-1802",
    "1520-4812"
  ],
  "landing_url": "https://hal.science/hal-05732826v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
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    ],
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    ],
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      "1.sdv.can"
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      "2.sdv.bbm.gtp"
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    [
      "openalex",
      "1312|RNA Interference and Gene Delivery"
    ]
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  "openalex": "W7158875691",
  "pdf_url": "https://hal.science/hal-05732826/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/9x7qvkxr3y6cx.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:44Z",
      "native_id": "hal-05732826",
      "source": "hal",
      "url": "https://hal.science/hal-05732826v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "hal:2.sdv.bbm.gtp",
      "subfield": "proteomics-metabolomics"
    },
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.ther",
      "subfield": "medicinal"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.can",
      "subfield": "oncology"
    }
  ],
  "title": "Lipid and Carbohydrate Modifications Enhance Potency of Antisense Oligonucleotides Targeting Oncogenic KRAS",
  "title_text": "Lipid and Carbohydrate Modifications Enhance Potency of Antisense Oligonucleotides Targeting Oncogenic KRAS",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:44Z",
  "url": "https://research.draconitic.com/paper/9x7qvkxr3y6cx",
  "venue": "Bioconjugate Chemistry",
  "versions": []
}