{
  "abstract": "Background: Psoriatic arthritis (PsA) and rheumatoid arthritis (RA) may present with overlapping hand and wrist symptoms, while their anatomical patterns of inflammation differ.\n\nObjective: To compare prespecified hand and wrist magnetic resonance imaging (MRI) features between PsA and RA and to assess selected exploratory associations, discriminatory performance, anatomical distributions and reader reliability.\n\nMethods: This retrospective case-control study included 41 patients with PsA and 41 with RA who underwent clinically acquired 3.0-T hand or wrist MRI. Research MRI features were assigned retrospectively by readers blinded to the clinical diagnosis. Between-group comparisons used available-case denominators. Each adjusted model included one MRI feature together with age, sex and symptom duration; Firth bias-reduced logistic regression was used for the sparse vascular-like signal feature.\n\nResults: Compared with RA, PsA had higher median scores for extracapsular soft tissue inflammation (7 vs. 2), periarthritis (8 vs. 4) and bead-like peritendinous effusion (1 vs. 0; all P <0.01). Study-defined prominent reticular vascular-like signal occurred in 35/41 patients with PsA and 2/41 with RA and showed a strong but imprecise adjusted association with PsA (odds ratio 85.02, 95% CI 15.07–479.83). RA had a higher median joint effusion score (5 vs. 2) and more frequent wrist synovitis (33/41 vs. 7/37) and wrist bone erosion (30/41 vs. 8/39; all P <0.01). Inter-reader coefficients ranged from 0.574 to 0.914 and intra-reader coefficients from 0.846 to 0.968.\n\nLimitations: The historical screening denominator and formal composite disease activity scores could not be reconstructed; one clinically diagnosed RA case did not meet the retrospective classification threshold; treatment exposure differed between groups; distal interphalangeal and ulnocarpal coverage was incomplete; and external validation was not performed.\n\nConclusion: In this exploratory cohort, extracapsular and enthesis-associated MRI findings favored PsA, whereas joint effusion and wrist synovitis or erosion favored RA. The study-defined vascular-like and bead-like features require independent validation before clinical use.",
  "abstract_shown": true,
  "affiliations": [
    "Hubei University of Chinese Medicine",
    "Department of Dermatology, Traditional Chinese and Western Medicine Hospital, Hubei University of Chinese Medicine",
    "Department of Dermatology, Wuhan No. 1 Hospital",
    "Department of Radiology, Wuhan No. 1 Hospital",
    "Tongji Medical College, Huazhong University of Science and Technology",
    "Department of Rheumatology and Immunology, Wuhan No. 1 Hospital",
    "School of Medicine, Jianghan University",
    "Hubei Province and Key Laboratory of Skin Infection and Immunity, Hubei Provincial Clinical Research Center for Infectious Skin Diseases",
    "Dermatology Hospital, Southern Medical University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Juan Huang"
    },
    {
      "affs": [
        3
      ],
      "name": "Shaohui Song"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Quanhong Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Qiuyu Fan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yue Li"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Yiqian Peng"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Yue Zhu"
    },
    {
      "affs": [
        2,
        6
      ],
      "name": "Gang Hu"
    },
    {
      "affs": [
        2,
        6
      ],
      "name": "Lang Yu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jingru Chen"
    },
    {
      "affs": [
        0,
        1,
        2,
        4,
        7
      ],
      "name": "Liuqing Chen"
    },
    {
      "affs": [
        8
      ],
      "name": "Ping Xia"
    },
    {
      "affs": [
        0,
        1,
        2,
        4,
        7
      ],
      "name": "Jinbo Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9x856207atdqn.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1945180",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727550/?tool=EBI",
  "id": "9x856207atdqn",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1945180/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2745|Spondyloarthritis Studies and Treatments"
    ]
  ],
  "openalex": "W7223060750",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1945180/pdf",
  "pmcid": "PMC13727550",
  "pmid": "42978735",
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9x856207atdqn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1945180",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1945180/full"
    },
    {
      "first_seen": "2026-11-04T15:20:45Z",
      "native_id": "PMC:PMC13727550",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727550"
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    {
      "first_seen": "2026-11-06T12:23:24Z",
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  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Extracapsular and joint-dominant hand and wrist MRI patterns in psoriatic and rheumatoid arthritis: an exploratory case-control study",
  "title_text": "Extracapsular and joint-dominant hand and wrist MRI patterns in psoriatic and rheumatoid arthritis: an exploratory case-control study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:43Z",
  "url": "https://research.draconitic.com/paper/9x856207atdqn",
  "venue": "Frontiers in Immunology",
  "versions": []
}