{
  "abstract": "Given the broad therapeutic benefits of molecular hydrogen, gastrointestinal delivery of this gasotransmitter is attractive for treating localized inflammatory diseases, yet conventional H2-releasing formulations suffer from limited solubility and poor tunability. Here, we develop gas-releasing frameworks (GRFs) for effective H2 delivery to the gastrointestinal tract. GRFs provide 20,000-fold higher hydrogen storage than hydrogen-rich water (HRW), prevent burst leakage in acidic gastric fluid, and enable sustained, inflammation-targeted H2 release in the intestine. After H2 release, the dynamic framework sequesters toxic boron within a reconstituted Si-O-B architecture, promoting fecal rather than systemic boron accumulation and improving long-term biosafety. Consequently, GRFs outperform HRW in mitigating oxidative damage and inflammation in dextran sulfate sodium-induced colitis, radiation-induced colitis, and high-fat diet-induced non-alcoholic fatty liver disease. Collectively, these gas-releasing frameworks provide a feasible, safe, and translatable strategy for gastrointestinal delivery of therapeutic gases and treatment of inflammatory disorders.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Junna Lu"
    },
    {
      "name": "Xiaochun Xie"
    },
    {
      "name": "Chao Yang"
    },
    {
      "name": "Yidan Zhang"
    },
    {
      "name": "Xin Zhao"
    },
    {
      "name": "Huanfen Lu"
    },
    {
      "name": "Madi Sun"
    },
    {
      "name": "Fangman Chen",
      "orcid": "0000-0003-1054-8806"
    },
    {
      "name": "Yingshuai Wang"
    },
    {
      "name": "Dan Shao",
      "orcid": "0000-0002-5243-042X"
    },
    {
      "name": "Kam W. Leong",
      "orcid": "0000-0002-8133-4955"
    },
    {
      "name": "He Shen",
      "orcid": "0000-0002-9152-7945"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9xdycmt34n9j6.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78290-6",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736903/",
  "id": "9xdycmt34n9j6",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78290-6",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2746|Hydrogen's biological and therapeutic effects"
    ]
  ],
  "openalex": "W7220690129",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78290-6_reference.pdf",
  "pmcid": "PMC13736903",
  "pmid": "42982857",
  "published": "2026-10-06",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/9xdycmt34n9j6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-78290-6",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78290-6"
    },
    {
      "first_seen": "2026-11-09T12:22:15Z",
      "native_id": "PMC13736903",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-78290-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Hydrogen's biological and therapeutic effects",
      "subfield": "surgery"
    }
  ],
  "title": "Gastrointestinal tract delivery of hydrogen by dynamic gas-releasing frameworks",
  "title_text": "Gastrointestinal tract delivery of hydrogen by dynamic gas-releasing frameworks",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:15Z",
  "url": "https://research.draconitic.com/paper/9xdycmt34n9j6",
  "venue": "Nature Communications",
  "versions": []
}