{
  "abstract": "Long-term obesity treatment remains challenging due to high costs, adverse drug effects, and invasive surgical procedures. Here, we develop an adipocyte-targeted manganese-nucleic acid framework (MNF) with superoxide dismutase (SOD)-like activity. The MNF and allicin are co-encapsulated into a silk fibroin-sulfobutylether-β-cyclodextrin (SFSC) microneedle patch, enabling minimally invasive transdermal delivery specifically to subcutaneous adipose tissue. The combination of MNF and allicin exhibits synergistic effects in alleviating oxidative stress, reducing lipid accumulation, and suppressing M1 macrophage polarization and inflammation. Notably, treatment with MNF was observed to increase intracellular NAD⁺ levels, while allicin upregulates the SIRT1 signaling pathway. This cooperative action appears to engage the NAD⁺-SIRT1 axis, promoting a phenotypic shift of white adipocytes towards beige adipocytes. Collectively, this microneedle-based delivery system, which promotes a beige-like adipocyte phenotype through dual modulation, presents a promising strategy for long-term obesity management.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.",
    "Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), The Ministry of Agriculture and Rural Affairs of the P.R. China, Beijing, 100083, China.",
    "Key Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China. 201211@cau.edu.cn.",
    "Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), The Ministry of Agriculture and Rural Affairs of the P.R. China, Beijing, 100083, China. 201211@cau.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Teng Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Bingxin Huangfu"
    },
    {
      "affs": [
        0
      ],
      "name": "Shurong He"
    },
    {
      "affs": [
        0
      ],
      "name": "Fengyi Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiayi Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinru Chen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wentao Xu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kunlun Huang"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Xiaoyun He"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9xehjcs7fw81d.bib",
  "cited_by": 0,
  "doi": "10.1186/s12951-026-04857-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13721524",
  "id": "9xehjcs7fw81d",
  "issns": [
    "1477-3155"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958258",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2737|Adipose Tissue and Metabolism"
    ]
  ],
  "openalex": "W7172028679",
  "pdf_url": "https://europepmc.org/articles/PMC13721524?pdf=render",
  "pmcid": "PMC13721524",
  "pmid": "42958258",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/9xehjcs7fw81d.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958258",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958258"
    },
    {
      "first_seen": "2026-11-03T12:22:12Z",
      "native_id": "PMC13721524",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12951-026-04857-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Adipose Tissue and Metabolism",
      "subfield": "physiology"
    }
  ],
  "title": "Synergistic promotion of white-to-beige adipocyte transition by manganese-nucleic acid framework and allicin for alleviating obesity.",
  "title_text": "Synergistic promotion of white-to-beige adipocyte transition by manganese-nucleic acid framework and allicin for alleviating obesity.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:12Z",
  "url": "https://research.draconitic.com/paper/9xehjcs7fw81d",
  "venue": "Journal of nanobiotechnology",
  "versions": []
}