{
  "abstract": "Background\n\nEven though studies of repetitive transcranial magnetic stimulation (rTMS) have demonstrated improvements in cognitive function, we know little about what site of stimulation would be ideal for improving memory.Methods\n\nWe investigated two sites: (1) the dorsolateral prefrontal cortex (DLPFC); and (2) the lateral parietal cortex (LPC), a more novel site. Forty amnestic MCI participants were randomized to one of three rTMS groups: (1) active DLPFC; (2) active LPC; and (3) sham. After completing 20 sessions of MRI-neuronavigated, bilateral rTMS, the participants were followed for 6 months. The primary outcome/endpoint was the California Verbal Learning Test-II (CVLT-II) list learning score assessed at 1-week post intervention.Results\n\nThirty-seven of 40 randomized participants provided primary endpoint data. Compared with the sham group, the active LPC group performed significantly higher on CVLT-II list learning (p = .048; standardized mean difference (SMD) = 0.86). No significant differences in CVLT-II list learning were detected between the active DLPFC and sham groups (p = .629; SMD = 0.20). Exploratory analyses revealed that the active LPC group performed better than sham on CVLT-II long-delay recall at the 1-week-post primary endpoint (p = .004; SMD = 1.30), and higher on CVLT-II semantic clustering at the 3-month follow-up (p = .015, SMD = 1.16).Conclusion\n\nThe parietal cortex is a promising TMS target for improving memory function in MCI. More definitive trials are needed to compare the efficacy of parietal and DLPFC TMS for treatment of memory and cognitive impairment.",
  "abstract_shown": true,
  "affiliations": [
    "Sierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.",
    "Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.",
    "Palo Alto CA War Related Illness and Injury Study Center (CA WRIISC), US Department of Veterans Affairs, (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.",
    "Department of Neurology, Stanford University School of Medicine, Stanford, CA, 94305, USA.",
    "Department of Radiology, Division of Neuroimaging and Neurointervention, Stanford University Medical Center, Stanford, CA, 94305, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Joy L Taylor",
      "orcid": "0000-0002-5776-3995"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Beatriz Hernandez"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Laura C Lazzeroni"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "M Windy McNerney"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alesha Heath"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "J Wesson Ashford"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jauhtai Joseph Cheng"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Steven Chao"
    },
    {
      "affs": [
        0
      ],
      "name": "Priyanka Bhatt"
    },
    {
      "affs": [
        4
      ],
      "name": "Michael Iv"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Fatemeh S Mojabi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jerome A Yesavage"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9xgc62bz7mhg6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.dscb.2026.100322",
  "fulltext_url": "https://europepmc.org/articles/PMC13649325",
  "id": "9xgc62bz7mhg6",
  "issns": [
    "2666-4593"
  ],
  "landing_url": "https://europepmc.org/article/MED/42852183",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2808|Transcranial Magnetic Stimulation Studies"
    ]
  ],
  "openalex": "W7164916024",
  "pdf_url": "https://europepmc.org/articles/PMC13649325?pdf=render",
  "pmcid": "PMC13649325",
  "pmid": "42852183",
  "published": "2026-06-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9xgc62bz7mhg6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42852183",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42852183"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Transcranial Magnetic Stimulation Studies",
      "subfield": "neurology"
    }
  ],
  "title": "Parietal and prefrontal transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI): A pilot randomized clinical trial.",
  "title_text": "Parietal and prefrontal transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI): A pilot randomized clinical trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/9xgc62bz7mhg6",
  "venue": "Brain disorders (Amsterdam, Netherlands)",
  "versions": []
}