{
  "abstract": "PURPOSE: Dicarbonyls are reactive precursors of advanced glycation end-products. They are formed during food processing, and endogenously in humans during glycolysis and lipid peroxidation. Higher plasma dicarbonyls, particularly methylglyoxal (MGO), promote insulin resistance and type 2 diabetes, but the association between dietary dicarbonyls intake and type 2 diabetes is unknown. This study examined the associations between dietary dicarbonyls and type 2 diabetes incidence. METHODS: 11,995 incident type 2 diabetes cases and a sub-cohort of 15,797 controls from the prospective multi-center European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct cohort were included. Intakes of three major dicarbonyls MGO, glyoxal [GO], and 3-deoxyglucosone [3-DG] were estimated at baseline using dietary questionnaires. Type 2 diabetes risk according to dietary dicarbonyl intake was estimated by multivariable-adjusted hazard ratios from Prentice-weighted Cox-regression analyses. RESULTS: Higher intakes of MGO (sample-specific mean intake 3.4 ± 1.3 mg/d) and 3-DG (13.8 ± 10.5) were associated with lower incidence of type 2 diabetes (HR 0.92 [95% CI 0.90–0.95] for 1 SD higher MGO intake and 0.93 [0.90–0.95] for 1 SD higher 3-DG intake). No associations were observed for dietary GO. CONCLUSION: Participants who consumed more dietary dicarbonyls MGO and 3-DG had a lower risk to develop type 2 diabetes. This protective association contrasts with the harmful effects on type 2 diabetes risk reported for endogenously formed dicarbonyls.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 36,
  "authors": [
    {
      "name": "Kim Maasen"
    },
    {
      "name": "Ana-Lucia Mayen"
    },
    {
      "name": "Claudia Hana"
    },
    {
      "name": "Viktoria Knaze"
    },
    {
      "name": "Marleen M. J. van Greevenbroek"
    },
    {
      "name": "Simone J. P. M. Eussen"
    },
    {
      "name": "Charlotte Debras"
    },
    {
      "name": "Coen D. A. Stehouwer"
    },
    {
      "name": "Anne Tjønneland"
    },
    {
      "name": "Cecilie Kyrø"
    },
    {
      "name": "Daniel B. Ibsen"
    },
    {
      "name": "Christina C. Dah"
    },
    {
      "name": "Francesca Mancini"
    },
    {
      "name": "Nasser Laouali"
    },
    {
      "name": "Mariem Hajji"
    },
    {
      "name": "Matthias B. Schulze"
    },
    {
      "name": "Rashmita Bajracharya"
    },
    {
      "name": "Verena Katzke"
    },
    {
      "name": "Giovanna Masala"
    },
    {
      "name": "Fabrizio Pasanisi"
    },
    {
      "name": "Lorenzo Milani"
    },
    {
      "name": "Valeria Pala"
    },
    {
      "name": "Marta Farràs Mañé"
    },
    {
      "name": "Conchi Moreno-Iribas"
    },
    {
      "name": "Miguel Rodriguez-Barranco"
    },
    {
      "name": "Sandra Milena Colorado Yohar"
    },
    {
      "name": "Olatz Mokoroa"
    },
    {
      "name": "Keren Papier"
    },
    {
      "name": "Elisabete Weiderpass"
    },
    {
      "name": "Heinz Freisling"
    },
    {
      "name": "Nicholas J. Wareham"
    },
    {
      "name": "Nita G. Forouhi"
    },
    {
      "name": "Sofia Christakoudi"
    },
    {
      "name": "Philippe Vangrieken"
    },
    {
      "name": "Mazda Jenab"
    },
    {
      "name": "Casper G. Schalkwijk"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9xhq8ns777tpc.bib",
  "cited_by": 2,
  "doi": "10.1007/s00394-026-03904-0",
  "fulltext_url": null,
  "id": "9xhq8ns777tpc",
  "issns": [
    "1436-6207",
    "1436-6215"
  ],
  "landing_url": "https://hal.science/hal-05849872v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.bbm"
    ],
    [
      "openalex",
      "1308|Advanced Glycation End Products research"
    ]
  ],
  "openalex": "W7137899482",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00394-026-03904-0.pdf",
  "pmcid": null,
  "pmid": "41843191",
  "published": "2026-11-03",
  "publisher": "Springer Verlag",
  "ris": "https://research.draconitic.com/paper/9xhq8ns777tpc.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:20:19Z",
      "native_id": "hal-05849872",
      "source": "hal",
      "url": "https://hal.science/hal-05849872v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "hal:1.sdv.bbm",
      "subfield": "general"
    },
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study",
  "title_text": "Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:12Z",
  "url": "https://research.draconitic.com/paper/9xhq8ns777tpc",
  "venue": "European Journal of Nutrition",
  "versions": []
}