{
  "abstract": "The design of synthetic routes to complex, stereochemically rich targets remains one of the most demanding challenges in organic chemistry. To interrogate the strategic logic underlying such efforts, we curated and digitized over 3,000 classical total syntheses comprising close to 60,000 individual steps, now freely available as the AbSynth collection. Analyses across this data set reveal that synthesis planning cannot be reduced to purely local, one-step-at-a-time decision-making: known complexity metrics and scoring functions fail to vary monotonically along synthetic trajectories, and conventional bond-disconnection heuristics apply only sporadically and lack the specificity required for automation. Instead, our study shows that nearly half of all steps correspond to structurally unproductive - yet strategically essential - plateaus of skeletal complexity. Navigating these plateaus requires retrosynthetic algorithms to embrace multistep reasoning rather than incremental scoring. We identify several such multistep heuristics, including tolerable lengths of nonskeletal disconnections and the \"longevity\" of functional groups across routes, and anticipate that AbSynth will serve as a resource for uncovering additional trends in synthesis design. By providing a century-spanning, machine-readable data set of complete routes, this work offers a foundation for advancing chemical AI toward the complexity of human expert planning.",
  "abstract_shown": true,
  "affiliations": [
    "1904 Undergraduate Chemistry Club at the Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków30-387, Poland.",
    "Allchemy, Inc. , Highland, Indiana46322, United States.",
    "Institute of Organic Chemistry, Polish Academy of Sciences , Warsaw01-224, Poland.",
    "Center for Algorithmic and Robotized Synthesis (CARS), Institute for Basic Science (IBS), Ulsan44919, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 33,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maciej Czuba"
    },
    {
      "affs": [
        0
      ],
      "name": "Konrad Barnowski"
    },
    {
      "affs": [
        1
      ],
      "name": "Karol Molga"
    },
    {
      "affs": [
        0
      ],
      "name": "Zofia Pławecka"
    },
    {
      "affs": [
        1
      ],
      "name": "Agnieszka Wołos"
    },
    {
      "affs": [
        0
      ],
      "name": "Szymon Stodółkiewicz"
    },
    {
      "affs": [
        0
      ],
      "name": "Sebastian Baś",
      "orcid": "0000-0003-4692-5757"
    },
    {
      "affs": [
        2
      ],
      "name": "Wojciech Petrykowski",
      "orcid": "0009-0007-5490-8371"
    },
    {
      "affs": [
        1
      ],
      "name": "Wiktor Beker"
    },
    {
      "affs": [
        0
      ],
      "name": "Evan Saillard"
    },
    {
      "affs": [
        0
      ],
      "name": "Konrad Łęgowski"
    },
    {
      "affs": [
        1
      ],
      "name": "Rafał Roszak"
    },
    {
      "affs": [
        2
      ],
      "name": "Paweł Kowalczyk"
    },
    {
      "affs": [
        1
      ],
      "name": "Barbara Mikulak-Klucznik"
    },
    {
      "affs": [
        0
      ],
      "name": "Piotr Janasz"
    },
    {
      "affs": [
        0
      ],
      "name": "Emilia Mielke",
      "orcid": "0000-0002-8196-0104"
    },
    {
      "affs": [
        0
      ],
      "name": "Patrycja Pietruszewska",
      "orcid": "0009-0001-2915-8886"
    },
    {
      "affs": [
        0
      ],
      "name": "Maja Łazuchiewicz"
    },
    {
      "affs": [
        0
      ],
      "name": "Sylwia Wójcik"
    },
    {
      "affs": [
        0
      ],
      "name": "Jakub Zabielski"
    },
    {
      "affs": [
        0
      ],
      "name": "Dariusz Nostkiewicz"
    },
    {
      "affs": [
        0
      ],
      "name": "Gabriela Smaga",
      "orcid": "0009-0008-7820-8107"
    },
    {
      "affs": [
        2
      ],
      "name": "Ahmad Makkawi"
    },
    {
      "affs": [
        2
      ],
      "name": "Louis P J-L Gadina"
    },
    {
      "affs": [
        0
      ],
      "name": "Jakub Skoczek"
    },
    {
      "affs": [
        1
      ],
      "name": "Tomasz Klucznik"
    },
    {
      "affs": [
        0
      ],
      "name": "Maxence Deschamps"
    },
    {
      "affs": [
        2
      ],
      "name": "Anna Żądło-Dobrowolska",
      "orcid": "0000-0003-4240-9851"
    },
    {
      "affs": [
        2
      ],
      "name": "Michał Michalak",
      "orcid": "0000-0002-1193-1551"
    },
    {
      "affs": [
        1
      ],
      "name": "Sara Szymkuć"
    },
    {
      "affs": [
        2
      ],
      "name": "Daniel T Gryko"
    },
    {
      "affs": [
        2
      ],
      "name": "Yasemin Bilgi-Gadina"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Bartosz A Grzybowski",
      "orcid": "0000-0001-6613-4261"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9xt189twkj2za.bib",
  "cited_by": 0,
  "doi": "10.1021/jacs.6c08434",
  "fulltext_url": "https://europepmc.org/articles/PMC13587670",
  "id": "9xt189twkj2za",
  "issns": [
    "0002-7863",
    "1520-5126"
  ],
  "landing_url": "https://europepmc.org/article/MED/42915532",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1703|Computational Drug Discovery Methods"
    ]
  ],
  "openalex": "W7207766256",
  "pdf_url": "https://europepmc.org/articles/PMC13587670?pdf=render",
  "pmcid": "PMC13587670",
  "pmid": "42915532",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9xt189twkj2za.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42915532",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42915532"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "journal-openalex:1605|Chemical Reaction Mechanisms",
      "subfield": "organic"
    }
  ],
  "title": "AbSynth: A Century of Total Syntheses as a Machine-Readable Resource for Analyzing Strategic Logic in Organic Chemistry.",
  "title_text": "AbSynth: A Century of Total Syntheses as a Machine-Readable Resource for Analyzing Strategic Logic in Organic Chemistry.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/9xt189twkj2za",
  "venue": "Journal of the American Chemical Society",
  "versions": []
}