{
  "abstract": "Whether a molecular motor can spontaneously organize actin filaments into bundles has remained an open question despite decades of in vitro investigation. Here, we show that the dimeric myosin-X, essential for filopodia initiation and extension in cells, is capable of sorting actin filaments into parallel bundles, gathering barbed ends within 1-2 micrometers. We observe that myosin-X processivity is comparable on single filaments and on bundles induced by myosin-X or fascin. Upon reaching barbed ends, myosin-X slows down the addition or removal of actin subunits, in a myosin density-dependent manner. Furthermore, the funneling of myosin-X towards the remaining filaments at the bundle tip increases motor density and triggers dynamic clustering. Together, we propose that the motor activity of myosin-X is sufficient to initiate filopodia, independently of passive crosslinkers such as fascin or fimbrin.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Wouter Kools"
    },
    {
      "name": "Sara Faour"
    },
    {
      "name": "Aliette Carlier"
    },
    {
      "name": "Trayana Hristova"
    },
    {
      "name": "Maria Elena Sirkia"
    },
    {
      "name": "Ludivine Chaix"
    },
    {
      "name": "Antony Lee"
    },
    {
      "name": "Pascal Martin"
    },
    {
      "name": "Anne Houdusse"
    },
    {
      "name": "Guillaume Romet-Lemonne"
    },
    {
      "name": "Antoine Jégou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9xwpcsk02n7w1.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.08.749704",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.749704v1.full",
  "id": "9xwpcsk02n7w1",
  "issns": [],
  "landing_url": "https://hal.science/hal-05761015v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biochemistry"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.bbm"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.749704v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9xwpcsk02n7w1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "hal-05761015",
      "source": "hal",
      "url": "https://hal.science/hal-05761015v1"
    },
    {
      "first_seen": "2026-10-30T12:21:28Z",
      "native_id": "10.64898/2026.09.08.749704",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.08.749704v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biochemistry",
      "subfield": "general"
    },
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Myosin-X sorts actin filaments into parallel bundles and tunes barbed-end dynamics",
  "title_text": "Myosin-X sorts actin filaments into parallel bundles and tunes barbed-end dynamics",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:28Z",
  "url": "https://research.draconitic.com/paper/9xwpcsk02n7w1",
  "venue": "HAL",
  "versions": []
}