{
  "abstract": "Background: Esophagectomy carries substantial morbidity and mortality with advanced age being a known risk factor. This study aims to evaluate the outcome of esophagectomy in octogenarians in the context of increasing adoption of minimally invasive esophagectomy (MIE). Methods: A retrospective cohort study was conducted using the National Surgical Quality Improvement Program database. Patients undergoing esophagectomy were stratified by age (<80 and ≥80). Univariate and multivariable analysis were used to assess the age and patient-dependent factors with surgical outcomes. Results: Among 11,210 patients identified who underwent esophagectomy, 447 were octogenarians. Overall, octogenarians experienced higher rates of 30-day mortality (p = 0.004), LOS (p = 0.0001), and serious complications (p = 0.001). Within the subset of MIE patients, morbidity (p = 0.001) and mortality (p = 0.051) remain elevated but significance was not reached for LOS (p = 0.116) between the two age groups. Multivariable analysis confirmed that age ≥80 was independently associated with serious complications (p = 0.008), readmission (p = 0.015), and extended LOS (p = 0.001). However, it was not an independent predictor of reoperation or anastomotic leak. MIE significantly decreased the rate of overall complications and extended LOS with a trend towards decreased mortality (p = 0.065). Conclusions: Octogenarians experience significantly higher morbidity, mortality, and post-surgical care needs. While age is a risk factor, patient-specific comorbidities and frailty are critical determinants of outcome. Furthermore, surgical approaches have a significant impact on the outcome of patients post-esophagectomy with MIE narrowing the outcome gap between the two age groups. These findings underscore the necessity for meticulous patient selection, preoperative optimization, and shared decision-making when considering esophagectomy in this growing demographic.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, University of Calgary, North Tower 1014, 1441 29th Street NW, Calgary, AB T2N 4J8, Canada"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Joshua Xu",
      "orcid": "0000-0001-8318-5669"
    },
    {
      "affs": [
        0
      ],
      "name": "Mary Hou",
      "orcid": "0000-0002-6052-2535"
    },
    {
      "affs": [
        0
      ],
      "name": "Estifanos Debru"
    },
    {
      "affs": [
        0
      ],
      "name": "Neal Church"
    },
    {
      "affs": [
        0
      ],
      "name": "Philip Mitchell"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniel Meyer",
      "orcid": "0009-0003-1619-9763"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9xww9s2nw6abq.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15197590",
  "fulltext_url": null,
  "id": "9xww9s2nw6abq",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/19/7590",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Esophageal Cancer Research and Treatment"
    ]
  ],
  "openalex": "W7214986315",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/9xww9s2nw6abq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15197590",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/19/7590"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Esophageal Cancer Research and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Esophagectomy in Octogenarians in the Minimally Invasive Era: A NSQIP Analysis of Surgical Outcomes",
  "title_text": "Esophagectomy in Octogenarians in the Minimally Invasive Era: A NSQIP Analysis of Surgical Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:00Z",
  "url": "https://research.draconitic.com/paper/9xww9s2nw6abq",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}