{
  "abstract": "Extensive skin wounds pose significant clinical challenges due to delayed healing, persistent inflammation and insufficient tissue regeneration. Here, we develop a photocrosslinked dermatomimetic hydrogel (DA-Col/HA) with bioadhesiveness and spatiotemporal controllability, composed of dopamine-conjugated collagen type III (DA-Col) and hyaluronic acid (HA). The DA-Col/HA gel, by mimicking the native extracellular matrix, promotes wound healing through accelerating hemostasis and its antioxidant/anti-inflammatory activities, specifically by scavenging ROS and inducing macrophage M2 polarization. On the other hand, the half-life of retinoic acid (RA), a key regulator of epithelial differentiation, is increased by 1.4 times after being encapsulated in adipose-derived stem cell extracellular vesicles (ADSC-EVs). In an extensive wound rat model, the mixture of RA-loaded ADSC-EVs and DA-Col/HA gel (EVs@RA-gel) significantly accelerates wound closure and facilitates the formation of follicle-like structures through enhanced re-epithelialization, accelerated neovascularization, and collagen deposition. Altogether, this multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel offers a promising therapeutic strategy for treating extensive skin wounds.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China",
    "Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Corresponding authors.",
    "Department of Pharmacy, Hangzhou Third People’s Hospital, Hangzhou 310058, China; Corresponding authors.",
    "State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Corresponding authors."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiawen Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaochuan Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jialu Lang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qi Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuanyan Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shihui Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Di Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Luwen Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jucong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiahao Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiayi Ding"
    },
    {
      "affs": [
        2
      ],
      "name": "Wei Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Yongzhong Du"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9y3ahzp0bmcha.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ajps.2026.101204",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S1818087626000905",
  "id": "9y3ahzp0bmcha",
  "issns": [
    "1818-0876",
    "2221-285X"
  ],
  "landing_url": "https://doi.org/10.1016/j.ajps.2026.101204",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "lcc",
      "RM1-950"
    ],
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7214361820",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S1818087626000905/pdf",
  "pmcid": "PMC13715312",
  "pmid": "42953714",
  "published": "2026-09-25",
  "publisher": "KeAi Communications Co., Ltd.",
  "ris": "https://research.draconitic.com/paper/9y3ahzp0bmcha.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:44Z",
      "native_id": "a743508ac0484ebb947ac5f4598bfab6",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.ajps.2026.101204"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953714",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953714"
    },
    {
      "first_seen": "2026-11-01T12:22:39Z",
      "native_id": "PMC13715312",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ajps.2026.101204"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RM1-950",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel for enhanced extensive wound healing",
  "title_text": "Multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel for enhanced extensive wound healing",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:39Z",
  "url": "https://research.draconitic.com/paper/9y3ahzp0bmcha",
  "venue": "Asian Journal of Pharmaceutical Sciences",
  "versions": []
}