{
  "abstract": "Brain activity and breathing rate influence each other but it remains unclear how fine respiratory features vary across vigilance states. Using simultaneous nasal pressure and hippocampal local field potential recordings in freely-moving mice, we show that the position of respiratory pauses within breathing cycles distinguish Wake, Rapid Eye Movement (REM) and non-REM (NREM) sleep states. Model-based predictions of vigilance states based on respiratory features perform well even on animals outside of the training set, suggesting the rules are generalized. Respiratory features underwent specific changes at state transitions, such as progressive elimination of pauses after inhalation foreshadowing REM. During NREM, respiratory changes predicted moment-to moment sigma power variations beyond movement-defined packets delineated by micro-arousals, as pauses after inhalation fragmented NREM sleep into ∼30s windows of high sigma power. Overall, our findings reveal that respiratory features structure the macro- and micro-architecture of sleep, opening new windows into brain states through respiration.",
  "abstract_shown": true,
  "affiliations": [
    "Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France",
    "Univ. of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297",
    "IINS - Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] (Centre Broca Nouvelle-Aquitaine, 146 rue Léo-Saignat, CS 61292 CASE 130, 33076 Bordeaux cedex - France)",
    "Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 186",
    "Univ. of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, Bordeaux, France",
    "Sorbonne University, INSERM U1127, UMR CNRS 7225, Institut du Cerveau (ICM)",
    "Sorbonne Univ., INSERM, CNRS, Paris Brain Institute, Institut du Cerveau, ICM, U1127, UMR 7225, Paris, France. nicolas.chenouard@inserm.fr",
    "Univ. Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux, France. nicolas.chenouard@inserm.fr",
    "Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France. lisa.roux@cnrs.fr"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Giulio Casali",
      "orcid": "0000-0002-7724-2708"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Camille Miermon"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Geoffrey Terral",
      "orcid": "0000-0001-5253-8855"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pascal Ravassard",
      "orcid": "0000-0002-7500-3623"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tim Gervois",
      "orcid": "0009-0009-0951-8598"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Tiphaine Dolique"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Evan R. Harrell",
      "orcid": "0000-0002-4376-9405"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Alena Spitsyn"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Edith Lesburguères",
      "orcid": "0000-0003-4867-9449"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "David Jarriault",
      "orcid": "0000-0002-4082-7083"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Frédéric Gambino",
      "orcid": "0000-0002-2981-5030"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Nicolas Chenouard",
      "orcid": "0000-0001-6730-4066"
    },
    {
      "affs": [
        8
      ],
      "name": "Lisa Roux",
      "orcid": "0000-0003-3794-6468"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9y5g0xphkvxg9.bib",
  "cited_by": 6,
  "doi": "10.1038/s41467-026-73106-z",
  "fulltext_url": null,
  "id": "9y5g0xphkvxg9",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-73106-z",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "2805|Sleep and Wakefulness Research"
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  "pdf_url": "https://www.nature.com/articles/s41467-026-73106-z.pdf",
  "pmcid": "PMC13381926",
  "pmid": "42156372",
  "published": "2026-05-19",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/9y5g0xphkvxg9.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T13:20:49Z",
      "native_id": "W4393219879",
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      "url": "https://doi.org/10.1038/s41467-026-73106-z"
    }
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Sleep and Wakefulness Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Respiratory pauses highlight sleep architecture in mice",
  "title_text": "Respiratory pauses highlight sleep architecture in mice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:14Z",
  "url": "https://research.draconitic.com/paper/9y5g0xphkvxg9",
  "venue": "Nature Communications",
  "versions": []
}