{
  "abstract": "Background: Stress and pain are overlapping processes and exert bidirectional influences. Passiflora incarnata (passionflower) is a perennial plant that has long been used for its therapeutic effects. The primary objective of this study was to investigate the hypothesis that Passiflora incarnata L. extract exerts a protective effect against stress-induced hyperalgesia. Methods: Adult male Wistar rats were randomly assigned to 9 groups (n=6): the control group (no stress, no treatment), 2 PFE-only groups that received PFE (100 or 200 mg/kg) for 21 days without stress, an acute stress group (6 h restraint), a chronic stress group (6 h/day for 21 days), and stress groups orally pretreated with PFE (100 or 200 mg/kg) 1 hour before each stress session (1-day treatment for the acute protocol and 21 days for the chronic protocol). The thermal pain threshold was evaluated using the hot-plate test (52±0.5°C), and chemical nociception was assessed using the formalin test. All behavioral tests were conducted 24 h after the final stress session. Results: Stress (acute/chronic) elevated chemical (p<0.01–p<0.001) and thermal (p<0.001) nociception versus controls. PFE (both doses) reversed chemical hyperalgesia at 0–7 min (p<0.01/p<0.001) and 15–60 min (p<0.001) versus acute stress; only the high dose was effective during the 60–90 min phase versus chronic stress (p<0.01). In addition, PFE (100 mg/kg) reversed thermal hyperalgesia versus acute stress, and both doses alleviated hyperalgesia versus chronic stress (p<0.001). Conclusion: This research evaluates the potential modulatory role of Passiflora incarnata extract in pain perception under stress conditions, which may have implications for the management of stress-related pain disorders.",
  "abstract_shown": true,
  "affiliations": [
    "Neuroscience Research Center, Biomedical Research Institute, Golestan University of Medical Science, Gorgan, Iran"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Soghra Hesam"
    },
    {
      "affs": [
        0
      ],
      "name": "Fatemeh Piri"
    },
    {
      "affs": [
        0
      ],
      "name": "Hamid Sepehri"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9yj1pn7efg41e.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": null,
  "id": "9yj1pn7efg41e",
  "issns": [
    "2538-3736"
  ],
  "landing_url": null,
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC31-1245"
    ]
  ],
  "openalex": null,
  "pdf_url": "http://jcbr.goums.ac.ir/article-1-555-en.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-01",
  "publisher": "Golestan University Of Medical Sciences",
  "ris": "https://research.draconitic.com/paper/9yj1pn7efg41e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:41Z",
      "native_id": "819d974ef56148adb0d6461e2053d967",
      "source": "doaj",
      "url": null
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC31-1245",
      "subfield": "general"
    }
  ],
  "title": "Antinociceptive effect of hydroalcoholic extract of Passiflora incarnata L. in an animal model of hyperalgesia induced by acute and chronic immobilization stress",
  "title_text": "Antinociceptive effect of hydroalcoholic extract of Passiflora incarnata L. in an animal model of hyperalgesia induced by acute and chronic immobilization stress",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:41Z",
  "url": "https://research.draconitic.com/paper/9yj1pn7efg41e",
  "venue": "Journal of Clinical and Basic Research",
  "versions": []
}