{
  "abstract": "Glucocorticoid (GC) withdrawal remains a major challenge for lupus nephritis (LN). In this 20-year retrospective cohort, we evaluated whether B-lymphocyte stimulator (BLyS) inhibitors facilitated GC discontinuation. Among 702 LN patients, 553 were treated with standard-of-care alone, and 149 received add-on BLyS inhibitors (belimumab or telitacicept). Patients receiving BLyS inhibitors achieved a higher rate of GC withdrawal than those receiving standard-of-care alone (10.7% vs. 5.61%, p = 0.026). Kaplan-Meier analysis confirmed a higher cumulative incidence of GC withdrawal in the BLyS inhibitor group (p = 0.001). After adjusting for age, sex, Systemic Lupus Erythematosus Disease Activity Index, acute kidney injury, nephrotic syndrome, and renal histopathology, time-dependent Cox regression revealed that BLyS inhibitor therapy was independently associated with a higher GC withdrawal rate (hazard ratio [HR] = 7.97, 95% confidence interval [CI]: 4.11-15.5, p < 0.001). Exploratory subgroup analyses indicated that among GC‑discontinued patients, Class IV LN predominated in the BLyS inhibitor group, whereas Class V LN was more prevalent in controls. During follow-up, no renal flares occurred in BLyS inhibitor-treated patients who discontinued GCs, though there was no significant between-group difference. In conclusion, add-on BLyS inhibitor therapy may serve as a potential steroid withdrawal-permissive approach for LN, pending further prospective validation of its clinical applicability.",
  "abstract_shown": true,
  "affiliations": [
    "Peking University First Hospital, Peking University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jingjing Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Meng Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Minghui Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Tan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9yjk47wg8dg45.bib",
  "cited_by": 0,
  "doi": "10.1002/mco2.71113",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718938/?tool=EBI",
  "id": "9yjk47wg8dg45",
  "issns": [
    "2688-2663"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13718938",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2745|Systemic Lupus Erythematosus Research"
    ]
  ],
  "openalex": "W7224500814",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718938/pdf/?tool=EBI",
  "pmcid": "PMC13718938",
  "pmid": "42960000",
  "published": "2026-10-29",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/9yjk47wg8dg45.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13718938",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13718938"
    },
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42960000",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960000"
    },
    {
      "first_seen": "2026-11-02T12:22:52Z",
      "native_id": "PMC13718938",
      "source": "pmc",
      "url": "https://doi.org/10.1002/mco2.71113"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Systemic Lupus Erythematosus Research",
      "subfield": "general"
    }
  ],
  "title": "Additional B‐Lymphocyte Stimulator Inhibitors Treatment Facilitated Glucocorticoid Withdrawal in Lupus Nephritis Patients: A Real‐World Retrospective Observational Single‐Center Cohort Study",
  "title_text": "Additional B‐Lymphocyte Stimulator Inhibitors Treatment Facilitated Glucocorticoid Withdrawal in Lupus Nephritis Patients: A Real‐World Retrospective Observational Single‐Center Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:52Z",
  "url": "https://research.draconitic.com/paper/9yjk47wg8dg45",
  "venue": "MedComm",
  "versions": []
}