{
  "abstract": "Dengue, a mosquito-borne viral disease, is experiencing its largest surge in history, driven by climate and demographic change. Expanding transmission has highlighted previously under-recognised populations at heightened risk of severe disease, including people with multimorbidity and immunosuppression, for whom live-attenuated vaccines are contraindicated or unlicensed. This evolving epidemiology underscores the urgent need for safe and effective treatments for dengue, particularly for those with complex risk profiles compounded by socio-economic disadvantage. We examine ethical, regulatory, and implementation considerations to support World Health Organization target product profile development for dengue therapeutics. Our analysis highlights the need for better characterisation of risk groups, including through enhanced surveillance; co-produced approaches for their inclusion in research prioritisation, trials, and care; and strategies to address key barriers to access for all, such as rapid diagnostics. This framework has the potential to inform equitable development and delivery of countermeasures for other infectious threats to global health.",
  "abstract_shown": true,
  "affiliations": [
    "Ethox Centre, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom",
    "Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, United Kingdom",
    "Department of Paediatrics, Homerton Healthcare NHS Foundation Trust, London, United Kingdom",
    "Department of Infectious Diseases, University of Melbourne, Melbourne, Australia",
    "Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom",
    "Epidemic and Emerging Infections Directorate, United Kingdom Health Security Agency, London, United Kingdom"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Tess Johnson"
    },
    {
      "affs": [
        2
      ],
      "name": "Shanghavie Loganathan"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Euzebiusz Jamrozik"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Michael J Parker"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Xin Hui S Chan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9ym8p3qvtktq7.bib",
  "cited_by": 1,
  "doi": "10.1016/j.lanmic.2026.101466",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7619672/",
  "id": "9ym8p3qvtktq7",
  "issns": [
    "2666-5247"
  ],
  "landing_url": "https://doi.org/10.1016/j.lanmic.2026.101466",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7206192355",
  "pdf_url": "https://www.thelancet.com/pdfs/journals/lanmic/PIIS2666-5247(26)00121-7.pdf",
  "pmcid": "PMC7619672",
  "pmid": "42685739",
  "published": "2026-11-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9ym8p3qvtktq7.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:45Z",
      "native_id": "PMC7619672",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.lanmic.2026.101466"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Mosquito-borne diseases and control",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "WHO Target Product Profiles for Dengue Therapeutics: An Interdisciplinary Analysis of Ethical, Regulatory, and Implementation Considerations",
  "title_text": "WHO Target Product Profiles for Dengue Therapeutics: An Interdisciplinary Analysis of Ethical, Regulatory, and Implementation Considerations",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:42Z",
  "url": "https://research.draconitic.com/paper/9ym8p3qvtktq7",
  "venue": "The Lancet. Microbe",
  "versions": []
}