{
  "abstract": "Background: Esophageal squamous cell carcinoma (ESCC) is closely linked to chronic inflammation, but the transcriptional mechanisms connecting epithelial inflammatory remodeling with malignant transformation remain incompletely understood.\n\nMethods: We integrated secondary analysis of published single-cell epithelial transition-state data, virtual SP1 perturbation, TCGA analyses, xCell immune infiltration analysis, TIDE-based exploratory immunotherapy prediction, Co-IP/MS, and a 4NQO-induced mouse model to investigate SP1-associated network remodeling during ESCC carcinogenesis.\n\nResults: SP1 regulatory importance increased across pairwise epithelial state comparisons. In adjacent normal epithelial cells, virtual SP1 overexpression affected genes linked to inflammatory response, NF-κB-related signaling, epithelial stress remodeling, and proliferation. SP1 expression correlated with immune infiltration features and immune checkpoint gene expression, and TIDE analysis suggested an association with predicted immunotherapy-related features. SP1-binding partners were enriched in RNA metabolism, RNA splicing, and nuclear protein-complex annotations, suggesting potential non-canonical regulatory associations that require further experimental validation.\n\nConclusions: SP1 may represent a progressively enhanced transcriptional hub during inflammation-associated ESCC carcinogenesis, with state-dependent network remodeling spanning epithelial inflammatory stress, malignant transformation, and tumor immune features.",
  "abstract_shown": true,
  "affiliations": [
    "Shanxi Key Laboratory of Aging Mechanism Research and Translational Applications, Changzhi Medical College",
    "School of Basic Medical Sciences, Changzhi Medical College"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Bin Du"
    },
    {
      "affs": [
        1
      ],
      "name": "Jie Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Huimin Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaoya Xing"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinyue Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Pu Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9zkb5c7557bnb.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1919461",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719483/?tool=EBI",
  "id": "9zkb5c7557bnb",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1919461/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2746|Esophageal Cancer Research and Treatment"
    ]
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  "openalex": "W7222506797",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719483/pdf/?tool=EBI",
  "pmcid": "PMC13719483",
  "pmid": "42964320",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/9zkb5c7557bnb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1919461",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1919461/full"
    },
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13719483",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13719483"
    },
    {
      "first_seen": "2026-11-02T12:23:26Z",
      "native_id": "PMC13719483",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1919461"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Esophageal Cancer Research and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Regulatory network remodeling and potential non-canonical associations of the transcription factor SP1 during inflammation-to-cancer transformation in esophageal squamous cell carcinoma",
  "title_text": "Regulatory network remodeling and potential non-canonical associations of the transcription factor SP1 during inflammation-to-cancer transformation in esophageal squamous cell carcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:32Z",
  "url": "https://research.draconitic.com/paper/9zkb5c7557bnb",
  "venue": "Frontiers in Immunology",
  "versions": []
}