{
  "abstract": "Aims: Obesity is a complication of childhood craniopharyngioma that remains difficult to treat. We investigated whether semaglutide was associated with a decrease in BMI among adolescents with craniopharyngioma‐related obesity.\n\nMaterial and Methods: This multicentre retrospective study included 20 patients < 18 years old with craniopharyngioma and obesity (BMI > 2 WHO Z‐score) from 2019 to 2024 (source population: 139 children with craniopharyngioma, including 36 children with obesity). They received off‐label semaglutide with dose titration (0.25–2 mg/week), tailored to tolerance and clinical response. The primary outcome was the within‐patient comparison of BMI change from −12 months to treatment initiation and from initiation to +12 months.\n\nResults: At semaglutide initiation, patients were 14.0 ± 3.9 years old, the interval since craniopharyngioma diagnosis was 6.3 ± 4.7 years, and BMI was 33.4 ± 3.9 kg/m2 (3.2 ± 0.7 Z‐score). Tumour treatment was surgery alone (8/20), surgery and proton therapy (11/20), or proton therapy alone (1/20). All patients had growth hormone and TSH deficiency; 19/20 had ACTH and AVP deficiency. In the year before treatment, patients gained 3.5 ± 4.4 kg/m2 in BMI and 0.6 ± 1.6 in BMI Z‐score; after 1 year of semaglutide therapy, they lost 2.5 ± 3.9 kg/m2 in BMI and 0.5 ± 0.5 in BMI Z‐score (paired comparisons, p < 0.001 and p = 0.004, respectively). During treatment, BMI decreased by 10% or more in 40% of patients (95% CI: 19%–64%). Gastrointestinal side effects occurred in 30% of patients but were mild. No cases of treatment discontinuation, pituitary insufficiency decompensation or tumour recurrence were observed.\n\nConclusions: Semaglutide was associated with reversal of weight gain among adolescents with craniopharyngioma‐related obesity.",
  "abstract_shown": true,
  "affiliations": [
    "Endocrine, Bone Diseases and Genetics Unit Children's Hospital, Toulouse University Hospital Toulouse France",
    "Department of Pediatric Endocrinology CHU Bordeaux Bordeaux France",
    "Reference Center for Rare Obesity CHU Bordeaux Bordeaux France",
    "Department of Pediatric Endocrinology Assistance Publique‐Hôpitaux de Marseille Marseille France",
    "Reference Center for Rare Pituitary Diseases Marseille France",
    "Department of Pediatric Endocrinology Civil Hospices of Lyon Lyon France",
    "Reference Center for Rare Pituitary Diseases Civil Hospices of Lyon Lyon France",
    "Department of Pediatric Endocrinology University Hospital Angers France",
    "Reference Center for Rare Pituitary Diseases University Hospital Angers France",
    "Department of Pediatric Endocrinology Bicetre University Hospital Le Kremlin‐Bicêtre France",
    "Reference Center for Rare Pituitary Diseases Bicetre University Hospital Paris France",
    "Department of Pediatric Endocrinology CHU Robert Debré, Assistance Publique‐Hôpitaux de Paris Paris France",
    "Reference Center for Rare Disease of Growth and Development (CRESCENDO) Paris France",
    "Université Paris Cité Paris France",
    "Pediatric Endocrinology, Diabetology, Gynecology Department Necker–Enfants Malades University Hospital Paris France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Joanne Dornberger"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Pascal Barat"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Karine Aouchiche"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Kevin Perge"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Carine Villanueva"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Sarah Castets"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Natacha Bouhours‐Nouet"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Aurelie Donzeau"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Lucie Levaillant"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Cecile Teinturier"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Rachel Reynaud"
    },
    {
      "affs": [
        11,
        12,
        13
      ],
      "name": "Ahlam Azar‐Kolakez"
    },
    {
      "affs": [
        11,
        12,
        13
      ],
      "name": "Laetitia Martinerie"
    },
    {
      "affs": [
        12,
        13,
        14
      ],
      "name": "Dulanjalee Kariyawasam"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Regis Coutant",
      "orcid": "0000-0002-6332-4243"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9zsh8nsqvtkgx.bib",
  "cited_by": 0,
  "doi": "10.1111/dom.71403",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731059/",
  "id": "9zsh8nsqvtkgx",
  "issns": [
    "1462-8902",
    "1463-1326"
  ],
  "landing_url": "https://doi.org/10.1111/dom.71403",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2712|Pituitary Gland Disorders and Treatments"
    ]
  ],
  "openalex": "W7214590753",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.71403",
  "pmcid": "PMC13731059",
  "pmid": "42806285",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9zsh8nsqvtkgx.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:19Z",
      "native_id": "PMC13731059",
      "source": "pmc",
      "url": "https://doi.org/10.1111/dom.71403"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Pituitary Gland Disorders and Treatments",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Semaglutide for Treating Paediatric Craniopharyngioma‐Related Obesity: A Multicentre Case Series",
  "title_text": "Semaglutide for Treating Paediatric Craniopharyngioma‐Related Obesity: A Multicentre Case Series",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:19Z",
  "url": "https://research.draconitic.com/paper/9zsh8nsqvtkgx",
  "venue": "Diabetes, Obesity & Metabolism",
  "versions": []
}