{
  "abstract": "We performed a review of public microarray data that revealed a significant down-regulation of Rnd3 expression in hepatocellular carcinoma (HCC), as compared to nontumor liver. Rnd3/RhoE is an atypical RhoGTPase family member because it is always under its active GTP-bound conformation and not sensitive to classical regulators. Rnd3 down-regulation was validated by quantitative real-time polymerase chain reaction in 120 independent tumors. Moreover, Rnd3 down-expression was confirmed using immunohistochemistry on tumor sections and western blotting on human tumor and cell-line extracts. Rnd3 expression was significantly lower in invasive tumors with satellite nodules. Overexpression and silencing of Rnd3 in Hep3B cells led to decreased and increased three-dimensional cell motility, respectively. The short interfering RNA-mediated down-regulation of Rnd3 expression induced a loss of E-cadherin at cell-cell junctions that was linked to epithelial-mesenchymal transition through the up-regulation of the zinc finger E-box binding homeobox protein, ZEB2, and the down-regulation of miR-200b and miR-200c. Rnd3 knockdown mediated tumor hepatocyte invasion in a matrix-metalloproteinase-independent, and Rac1-dependent manner. Conclusion: Rnd3 down-regulation provides an invasive advantage to tumor hepatocytes, suggesting that RND3 might represent a metastasis suppressor gene in HCC.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Florence Grise"
    },
    {
      "name": "Sandra Sena"
    },
    {
      "name": "Aurélien Bidaud-Meynard"
    },
    {
      "name": "Jessica Baud"
    },
    {
      "name": "Jean-Baptiste Hiriart"
    },
    {
      "name": "Kassem Makki"
    },
    {
      "name": "Nathalie Dugot-Senant"
    },
    {
      "name": "Cathy Staedel"
    },
    {
      "name": "Paulette Bioulac-Sage"
    },
    {
      "name": "Jessica Zucman-Rossi"
    },
    {
      "name": "Jean Rosenbaum"
    },
    {
      "name": "Violaine Moreau"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a0713620f9dsh.bib",
  "cited_by": 62,
  "doi": "10.1002/hep.25568",
  "fulltext_url": null,
  "id": "a0713620f9dsh",
  "issns": [
    "0270-9139",
    "1527-3350"
  ],
  "landing_url": "https://hal.science/hal-05738661v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Mechanisms of cancer metastasis"
    ]
  ],
  "openalex": "W2013113421",
  "pdf_url": "https://hal.science/hal-05738661/document",
  "pmcid": null,
  "pmid": "22234932",
  "published": "2026-09-04",
  "publisher": "Wiley-Blackwell",
  "ris": "https://research.draconitic.com/paper/a0713620f9dsh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "hal-05738661",
      "source": "hal",
      "url": "https://hal.science/hal-05738661v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Mechanisms of cancer metastasis",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion",
  "title_text": "Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:29Z",
  "url": "https://research.draconitic.com/paper/a0713620f9dsh",
  "venue": "Hepatology",
  "versions": []
}