{
  "abstract": "Background: Although treatment burden significantly affects the management of pediatric asthma, no specific instrument exists to measure it in this population. Objective: To develop and validate a questionnaire measuring treatment burden in pediatric asthma from both children's and parents' perspectives. Methods: We conducted semi-structured interviews with 20 children with asthma (aged 8-12 years) and their parents to identify relevant components of treatment burden. Items were refined through a Delphi process with pediatric pulmonologists. The questionnaire was then validated in 202 parent-child dyads across eight teaching hospitals. We assessed psychometric properties, including factorial validity, internal consistency, construct validity, and test-retest reliability. Results: The final questionnaire was composed of seven items for children (Cronbach α = 0.78) and 13 items for parents (Cronbach α = 0.86). Both versions demonstrated strong construct validity, with significant correlations with quality of life measures (r = -0.52 for children and r = -0.53 for parents) and global impression of treatment burden (r = +0.66 for children and r = +0.77 for parents). Test-retest reliability was acceptable for both children (intraclass correlation coefficient = 0.72) and parents (intraclass correlation coefficient = 0.80). Higher treatment burden scores were associated with being female (for both children and caregivers), having multiple scheduled visits, and poor asthma control. Parent and child scores showed moderate correlation (r = 0.33; P < .01), highlighting the importance of capturing both perspectives. Conclusion: This validated questionnaire provides a reliable tool for measuring treatment burden in pediatric asthma, enabling clinicians to better understand and address the impact of asthma management on children and their families.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Sophie Schmartz"
    },
    {
      "name": "Pierrick Cros"
    },
    {
      "name": "Camille Cisterne"
    },
    {
      "name": "Ania Carsin"
    },
    {
      "name": "Thomas Perrin"
    },
    {
      "name": "Stéphanie Wanin"
    },
    {
      "name": "Alexandra Masson"
    },
    {
      "name": "Céline Ménétrey"
    },
    {
      "name": "Charlotte Roy"
    },
    {
      "name": "Clément Poirault"
    },
    {
      "name": "Rosy-Varte Jacobs"
    },
    {
      "name": "Rola Abou Taam"
    },
    {
      "name": "Lisa Giovannini-Chami"
    },
    {
      "name": "David Drummond"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a0b9c0x6zz6hg.bib",
  "cited_by": 2,
  "doi": "10.1016/j.jaip.2025.12.021",
  "fulltext_url": null,
  "id": "a0b9c0x6zz6hg",
  "issns": [
    "2213-2198",
    "2213-2201"
  ],
  "landing_url": "https://inserm.hal.science/inserm-05791477v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7117252608",
  "pdf_url": "https://inserm.hal.science/inserm-05791477/document",
  "pmcid": null,
  "pmid": "41453687",
  "published": "2026-10-10",
  "publisher": "Elsevier / American Academy of Allergy, Asthma & Immunology / American Academy of Allergy, Asthma and Immunology",
  "ris": "https://research.draconitic.com/paper/a0b9c0x6zz6hg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "inserm-05791477",
      "source": "hal",
      "url": "https://inserm.hal.science/inserm-05791477v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "Development and Validation of a Questionnaire Measuring Treatment Burden in Pediatric Asthma",
  "title_text": "Development and Validation of a Questionnaire Measuring Treatment Burden in Pediatric Asthma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/a0b9c0x6zz6hg",
  "venue": "Journal of Allergy and Clinical Immunology: In Practice",
  "versions": []
}