{
  "abstract": "Here we present a major advancement of the OrthoFinder method. This extends OrthoFinder's high-accuracy comparative genomic framework to provide substantially enhanced scalability and accuracy. Specifically, we show that enhanced phylogenetic delineation of orthogroups provides a 7% relative increase in orthogroup inference accuracy. We further demonstrate that a new gene assignment method substantially reduces overall runtime RAM usage without compromising accuracy. The latest version of OrthoFinder is available via GitHub at https://github.com/OrthoFinder/OrthoFinder .",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biology, University of Oxford, Oxford, UK",
    "Department of Biology, University of Oxford, Oxford, UK. steven.kelly@biology.ox.ac.uk"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "David Emms",
      "orcid": "0000-0002-9065-8978"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Liu",
      "orcid": "0009-0000-2084-7776"
    },
    {
      "affs": [
        0
      ],
      "name": "Laurence J. Belcher",
      "orcid": "0000-0003-2392-6503"
    },
    {
      "affs": [
        0
      ],
      "name": "Jonathan Holmes",
      "orcid": "0009-0001-0440-8404"
    },
    {
      "affs": [
        1
      ],
      "name": "Steven L. Kelly",
      "orcid": "0000-0001-8583-5362"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a0bhetfpadnzv.bib",
  "cited_by": 85,
  "doi": "10.1038/s41592-026-03126-6",
  "fulltext_url": null,
  "id": "a0bhetfpadnzv",
  "issns": [
    "1548-7091",
    "1548-7105"
  ],
  "landing_url": "https://doi.org/10.1038/s41592-026-03126-6",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Genomics and Phylogenetic Studies"
    ]
  ],
  "openalex": "W7163984798",
  "pdf_url": "https://www.nature.com/articles/s41592-026-03126-6.pdf",
  "pmcid": "PMC13346109",
  "pmid": "42265210",
  "published": "2026-06-09",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/a0bhetfpadnzv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:46Z",
      "native_id": "W7163984798",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41592-026-03126-6"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Genomics and Phylogenetic Studies",
      "subfield": "molecular-biology"
    }
  ],
  "title": "OrthoFinder: improved phylogenetic orthology inference with enhanced accuracy and scalability",
  "title_text": "OrthoFinder: improved phylogenetic orthology inference with enhanced accuracy and scalability",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T13:20:46Z",
  "url": "https://research.draconitic.com/paper/a0bhetfpadnzv",
  "venue": "Nature Methods",
  "versions": []
}