{
  "abstract": "Allergic transfusion reactions (ATR) are potentially lethal adverse events that occur in ∼0.3% to 6% of plasma or platelet transfusions. The main mechanism described is an immunoglobulin E (IgE)–mediated response to donor proteins, such as IgA and haptoglobin in deficient patients. Recently, in a nationwide retrospective observational study, we reported that group O recipients of group B or AB platelet concentrates or plasma were at significantly higher risk of severe ATR than recipients with other ABO combinations. Given the antigenic proximity between group B determinant and the galactose-α-1,3-galactose (α-Gal) epitope, we hypothesize a role for α-Gal IgE–mediated sensitization in these ATR. In this report, we investigated the presence of anti–α-Gal IgE in a cohort of 59 patients with severe ATR. We found that group O recipients of group B or AB blood components (plasma or platelet concentrates) were substantially more likely to exhibit high titers of group B cross-reactive anti–α-Gal IgE than other patients, supporting our hypothesis that α-Gal sensitization underlies these severe ATR. These findings suggest that α-Gal sensitization is an additional mechanism responsible for ATR in major ABO-incompatible transfusion and should be systematically explored in group O patients having received group B/AB plasma or platelets.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Luc de Chaisemartin"
    },
    {
      "name": "Virginie de la Taille"
    },
    {
      "name": "Pascale Nicaise-Roland"
    },
    {
      "name": "Lucile Malard"
    },
    {
      "name": "Cléo Beuscart"
    },
    {
      "name": "Aurélie Gouel-Chéron"
    },
    {
      "name": "Syria Laperche"
    },
    {
      "name": "Pierre Tiberghien"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a0g42gd2j66q0.bib",
  "cited_by": 5,
  "doi": "10.1182/blood.2025032045",
  "fulltext_url": null,
  "id": "a0g42gd2j66q0",
  "issns": [
    "0006-4971",
    "1528-0020"
  ],
  "landing_url": "https://u-paris.hal.science/hal-05735556v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2720|Blood groups and transfusion"
    ]
  ],
  "openalex": "W7151812402",
  "pdf_url": "https://u-paris.hal.science/hal-05735556/document",
  "pmcid": null,
  "pmid": "41949618",
  "published": "2026-06-18",
  "publisher": "American Society of Hematology",
  "ris": "https://research.draconitic.com/paper/a0g42gd2j66q0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:27Z",
      "native_id": "hal-05735556",
      "source": "hal",
      "url": "https://u-paris.hal.science/hal-05735556v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Severe allergic transfusion reactions to group B/AB plasma or platelets in group O recipients are linked to α-Gal sensitization",
  "title_text": "Severe allergic transfusion reactions to group B/AB plasma or platelets in group O recipients are linked to α-Gal sensitization",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:27Z",
  "url": "https://research.draconitic.com/paper/a0g42gd2j66q0",
  "venue": "Blood",
  "versions": []
}