{
  "abstract": "Corchorus olitorius L. seeds are a rich source of endophytic fungi, which afford many cytotoxic secondary metabolites. The fungus was taxonomically identified via sequencing as Penicillium sp. ArD1 (GenBank accession OQ520320; 99.82% similarity to P. oxalicum strain MK371716.1). The fungal extract was subjected to chromatographic separation, leading to the isolation and structural elucidation of four compounds: two naphtho-pyrones ((1) and (2)), the cyclic pentapeptide malformin A1 (3), and the fatty acid Tridecanoic acid (4). Structures were confirmed using extensive 1D and 2D NMR as well as mass spectrometry. The isolated metabolites were evaluated for cytotoxicity against human lung carcinoma cell lines A549 and H1299. Among the isolated metabolites, malformin A1 (3) exhibited the most pronounced cytotoxic activity against the tested non-small-cell lung cancer cell lines, A549 and H1299. Molecular docking analysis further suggested a possible interaction of malformin A1 with MMP-9. These findings highlight the biological activity of malformin A1 and support further investigation of its cytotoxic effects and possible molecular mechanisms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacognosy, Faculty of Pharmacy, Deraya University 61111 New-Minia City Egypt",
    "Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University 61111 New-Minia Egypt",
    "Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University Guangzhou 511436 China",
    "Guangdong Key Laboratory for Research and Development of Natural Drugs, College of Pharmacy, Guangdong Medical University Dongguan 523808 China",
    "Department of Pharmacognosy, Faculty of Pharmacy, Minia University Minia 61519 Egypt",
    "Department of Pharmacognosy, Faculty of Pharmacy, Minia National University (MNU) New-Minia Egypt"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Arwa Mortada Ahmed",
      "orcid": "0009-0008-0129-1766"
    },
    {
      "affs": [
        1
      ],
      "name": "Islam M. Abdel-Rahman"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiabao Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Jianye Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Jun Wu"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Usama Ramadan Abdelmohsen",
      "orcid": "0000-0002-1014-6922"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Mostafa A. Fouad",
      "orcid": "0000-0002-3909-3537"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Basma Khalaf Mahmoud",
      "orcid": "0009-0008-1872-0504"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a1674h8shxrey.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra04888a",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735794/",
  "id": "a1674h8shxrey",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://doi.org/10.1039/d6ra04888a",
  "language": "en",
  "licence": "CC-BY-NC-3.0",
  "licence_label": "CC BY-NC 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2402|Microbial Natural Products and Biosynthesis"
    ]
  ],
  "openalex": "W7125563733",
  "pdf_url": "https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra04888a/15046217/d6ra04888a.pdf",
  "pmcid": "PMC13735794",
  "pmid": "42991389",
  "published": "2026-11-05",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/a1674h8shxrey.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:25Z",
      "native_id": "PMC13735794",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra04888a"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2402|Microbial Natural Products and Biosynthesis",
      "subfield": "microbiology"
    }
  ],
  "title": "Cytotoxic metabolites from the endophytic fungus Penicillium sp. ArD1 derived from Corchorus olitorius seeds",
  "title_text": "Cytotoxic metabolites from the endophytic fungus Penicillium sp. ArD1 derived from Corchorus olitorius seeds",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:25Z",
  "url": "https://research.draconitic.com/paper/a1674h8shxrey",
  "venue": "RSC Advances",
  "versions": []
}