{
  "abstract": "Objectives: Low-dose ionizing radiation (LDIR, ≤100 mGy) is a public health concern due to its extensive use in diagnostic and therapeutic imaging. This study examined somatic variants (SV) among Korean industrial radiographers exposed to LDIR using whole-genome sequencing (WGS).\n\nMethods: WGS data from 65 workers (mean age 36.7 years) collected between 2016 and 2023 were analyzed. Participants had a mean employment duration of 12.7 years and an average cumulative radiation dose of 33.9 mSv from National Dose Registry records. SV were identified via the GATK Mutect2 single-sample workflow applied to peripheral blood-derived DNA and sequentially filtered using standard pipelines, including FilterMutectCalls, population frequency, recurrent artifacts, Funcotator annotation, and manual Integrative Genomics Viewer review.\n\nResults: A total of 105 170 somatic variants were identified, with a median of 1744 variants per individual, approximately 98% of which were single nucleotide variants. Cumulative radiation dose showed a significant positive correlation with total SV burden (R=0.32, P=0.013), including both coding (R=0.34, P=0.008) and non-coding regions (R=0.31, P=0.015). Age, smoking, alcohol consumption, hypertension, and hyperlipidemia were not significantly associated with variant burden.\n\nConclusions: These WGS-based findings provide preliminary insight into blood-derived SV patterns among occupationally exposed radiation workers. Given the small sample size, blood-only design, and absence of matched unexposed controls, the findings should be interpreted as hypothesis-generating and require validation in larger longitudinal studies with comprehensive exposure assessment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Occupational & Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea .",
    "Research Institute for Convergence of Biomedical Science & Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea .",
    "Department of Research, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea .",
    "Medical Research Institute, Pusan National University, Yangsan, Republic of Korea .",
    "National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea .",
    "Department of Medical Sciences, Graduate School, Soonchunhyang University, Asan, Chungnam, Republic of Korea .",
    "Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan, Chungnam, Republic of Korea .",
    "Institute for Molecular Metabolism Innovation, Soonchunhyang University, Asan 31538, Republic of Korea",
    "FNCT Biotech, Inc . Seoul, Republic of Korea .",
    "Division of Respiratory & Allergy, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea .",
    "Department of Oral Biochemistry, Dental & Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea .",
    "Department of Convergence Medicine, School of Medicine, Pusan National University, Yangsan, Republic of Korea .",
    "Transplantation Research Center, Research Institute for Convergence of Biomedical Science & Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea .",
    "Department of Periodontology & Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea .",
    "Periodontal Disease Signaling Network Research Center, School of Dentistry, Pusan National University, Yangsan, Republic of Korea .",
    "Department of Oral Pathology, Dental & Life Science Institute, Pusan National University, Yangsan, Republic of Korea",
    "Department of Biomedical Informatics School of Medicine, Pusan National University, Yangsan, Republic of Korea .",
    "Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea ."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kihun Kim"
    },
    {
      "affs": [
        2
      ],
      "name": "Junho Kang"
    },
    {
      "affs": [
        3
      ],
      "name": "Dong Min Lim"
    },
    {
      "affs": [
        4
      ],
      "name": "Seongjae Jang"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Younghyun Lee"
    },
    {
      "affs": [
        4
      ],
      "name": "Yang Hee Lee"
    },
    {
      "affs": [
        4
      ],
      "name": "Hyo Jin Yoon"
    },
    {
      "affs": [
        4
      ],
      "name": "SuSan Yang"
    },
    {
      "affs": [
        4
      ],
      "name": "Seung Hyun Kim"
    },
    {
      "affs": [
        4
      ],
      "name": "Dalnim Lee"
    },
    {
      "affs": [
        4
      ],
      "name": "Won Il Jang"
    },
    {
      "affs": [
        4
      ],
      "name": "Hyoju Sung"
    },
    {
      "affs": [
        8
      ],
      "name": "Min-Jung Kim"
    },
    {
      "affs": [
        9
      ],
      "name": "Eunjeong Son"
    },
    {
      "affs": [
        10
      ],
      "name": "Hyung-Sik Kim"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Dongjun Lee"
    },
    {
      "affs": [
        13,
        14,
        15
      ],
      "name": "Hae Ryoun Park"
    },
    {
      "affs": [
        4
      ],
      "name": "Songwon Seo"
    },
    {
      "affs": [
        1,
        16,
        17
      ],
      "name": "Yun Hak Kim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a1949a64rqxnc.bib",
  "cited_by": 0,
  "doi": "10.5271/sjweh.4317",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732785/",
  "id": "a1949a64rqxnc",
  "issns": [
    "0355-3140",
    "1795-990X"
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  "landing_url": "https://doi.org/10.5271/sjweh.4317",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
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      "openalex",
      "2741|Effects of Radiation Exposure"
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  "pdf_url": "https://www.sjweh.fi/download.php?abstract_id=4317&file_nro=1",
  "pmcid": "PMC13732785",
  "pmid": "42390370",
  "published": "2026-11-01",
  "publisher": "Nordic Association of Occupational Safety and Health",
  "ris": "https://research.draconitic.com/paper/a1949a64rqxnc.ris",
  "sources": [
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  "subjects": [
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      "origin": "openalex:2741|Effects of Radiation Exposure",
      "subfield": "imaging"
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  ],
  "title": "Genomic insights into somatic mutations from occupational exposure to low-dose ionizing radiation",
  "title_text": "Genomic insights into somatic mutations from occupational exposure to low-dose ionizing radiation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:42Z",
  "url": "https://research.draconitic.com/paper/a1949a64rqxnc",
  "venue": "Scandinavian Journal of Work, Environment & Health",
  "versions": []
}