{
  "abstract": "Background\n\nThe role of hilar lymph node metastasis (LNM) in intrahepatic cholangiocarcinoma (ICC) was investigated and a simple postoperative risk-stratification system combining LNM and preoperative anemia was established to predict the outcome of patients with ICC after curative resection.Methods\n\nA retrospective analysis was conducted on 384 patients who underwent hepatectomy for ICC. Both postoperative clinical outcomes and long-term oncological outcomes were systematically evaluated. Subsequently, predictive models were developed to assess the risks of tumor recurrence, overall survival (OS) and recurrence-free survival (RFS).Results\n\nThe primary cohort demonstrated 65.2% recurrence and 13.1-month median RFS (1-/3-/5-year rates: 51.9%/37.6%/25.0%), with median OS of 31.1 months (1-/3-/5-year rates: 81.8%/63.3%/54.1%). The external validation cohort showed 79.4% recurrence, 11.7-month median RFS (1-/3-/5-year rates: 49.5%/11.8%/5.9%), and 16.2-month median OS (1-/3-/5-year rates: 98.1%/10.4%/6.4%). We developed nomograms for recurrence, OS, and RFS incorporating LNM and preoperative anemia, yielding C-indices of 0.881, 0.802, and 0.758, respectively. Risk-stratified analysis revealed significant prognostic discrimination: high-risk patients demonstrated substantially inferior 5-year OS compared to low-risk patients (19.6% vs. 86.6%, P < 0.001), with median OS of 16.7 months versus not reached. Similarly, median RFS declined from not reached in low-risk patients to 6.1 months in high-risk patients. These results were confirmed in the external validation cohort, where high-risk status corresponded to a median OS of 14.4 months and median RFS of 8.1 months (both P < 0.001).Conclusions\n\nThe integration of LNM status and preoperative anemia emerges as a novel and clinically valuable prognostic indicator, effectively predicting outcomes in patients with ICC following curative resection, thereby providing tailored clinical guidance for postoperative adjuvant therapy selection and intensive surveillance planning.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, 628 Zhenyuan Road, Shenzhen, 518107, China.",
    "Department of Liver Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, China.",
    "State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.",
    "Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.",
    "Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.",
    "Department of Orthopedics, Shen Zhen Guangming District People's Hospital, Shenzhen, China.",
    "Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.",
    "Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.",
    "Department of Pancreatic and Metabolic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.",
    "Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, 628 Zhenyuan Road, Shenzhen, 518107, China. tangdi@sysush.com.",
    "Department of Liver Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, China. weiwei@sysucc.org.cn.",
    "State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. weiwei@sysucc.org.cn.",
    "Department of Liver Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, China. guorp@sysucc.org.cn.",
    "State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. guorp@sysucc.org.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Min Deng"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Benyi He"
    },
    {
      "affs": [
        3
      ],
      "name": "Zenghai Lin"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Deyao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuxiong Qiu"
    },
    {
      "affs": [
        0
      ],
      "name": "Dong Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yajun Tang"
    },
    {
      "affs": [
        5
      ],
      "name": "Xianchao Guo"
    },
    {
      "affs": [
        6
      ],
      "name": "Guojia Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Qin"
    },
    {
      "affs": [
        7
      ],
      "name": "Hao Cai"
    },
    {
      "affs": [
        8
      ],
      "name": "Yudong Qiu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zubing Chen"
    },
    {
      "affs": [
        9
      ],
      "name": "Di Tang"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Wei Wei"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Rongping Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a1dv4p02vn1d6.bib",
  "cited_by": 0,
  "doi": "10.1186/s12885-026-16604-z",
  "fulltext_url": "https://europepmc.org/articles/PMC13679262",
  "id": "a1dv4p02vn1d6",
  "issns": [
    "1471-2407"
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  "landing_url": "https://europepmc.org/article/MED/42897511",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
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      "2746|Cholangiocarcinoma and Gallbladder Cancer Studies"
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  "pdf_url": "https://europepmc.org/articles/PMC13679262?pdf=render",
  "pmcid": "PMC13679262",
  "pmid": "42897511",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/a1dv4p02vn1d6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cholangiocarcinoma and Gallbladder Cancer Studies",
      "subfield": "surgery"
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  ],
  "title": "A prognostic model combining hilar lymph node metastasis and preoperative anemia to predict outcomes after curative resection of intrahepatic cholangiocarcinoma.",
  "title_text": "A prognostic model combining hilar lymph node metastasis and preoperative anemia to predict outcomes after curative resection of intrahepatic cholangiocarcinoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:03Z",
  "url": "https://research.draconitic.com/paper/a1dv4p02vn1d6",
  "venue": "BMC cancer",
  "versions": []
}