{
  "abstract": "Background: Chronic rhinosinusitis (CRS) is associated with lower airway diseases, but its relationship with mucus plugging remains unclear. We investigated the association between CRS and lower airway mucus plugging. Methods: This single-center retrospective observational study included patients who underwent paranasal sinus computed tomography and chest high-resolution computed tomography. Associations between CRS and mucus plugging were evaluated, including phenotype-stratified analyses according to eosinophilic CRS (ECRS) status. Results: Among 97 patients, 51 had CRS and 46 did not. Mucus plugging was more frequent in patients with CRS than in those without CRS (41.2% vs. 10.9%, p = 0.001), and mucus plug scores were higher in the CRS group (p = 0.002). CRS remained independently associated with mucus plugging after adjustment for asthma and bronchiectasis (adjusted odds ratio, 4.06; 95% confidence interval, 1.30–12.7; p = 0.016). Mucus plugging was more prevalent in both the non-ECRS and ECRS groups than in the non-CRS group, with no significant difference between the two CRS phenotypes. Conclusions: CRS remained associated with mucus plugging after adjustment for asthma and bronchiectasis. Mucus plugging may represent an underrecognized radiological feature of the lower airways in CRS.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan",
    "Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Akane Masuda"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuta Kono",
      "orcid": "0000-0002-4098-496X"
    },
    {
      "affs": [
        1
      ],
      "name": "Ryo Maruyama"
    },
    {
      "affs": [
        0
      ],
      "name": "Haruka Motohashi"
    },
    {
      "affs": [
        0
      ],
      "name": "Naoya Aoshiba"
    },
    {
      "affs": [
        0
      ],
      "name": "Mariko Kogami"
    },
    {
      "affs": [
        0
      ],
      "name": "Mayuko Ishiwari"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryota Kikuchi",
      "orcid": "0000-0002-0854-3494"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenichi Kobayashi"
    },
    {
      "affs": [
        1
      ],
      "name": "Kiyoaki Tsukahara"
    },
    {
      "affs": [
        0
      ],
      "name": "Shinji Abe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a1v5sjvx915r5.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15197609",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665754/?tool=EBI",
  "id": "a1v5sjvx915r5",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13665754",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2733|Sinusitis and nasal conditions"
    ]
  ],
  "openalex": "W7214949502",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665754/pdf/?tool=EBI",
  "pmcid": "PMC13665754",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/a1v5sjvx915r5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "PMC:PMC13665754",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13665754"
    },
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15197609",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/19/7609"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Sinusitis and nasal conditions",
      "subfield": "general"
    }
  ],
  "title": "Chronic Rhinosinusitis Is Associated with Lower Airway Mucus Plugging",
  "title_text": "Chronic Rhinosinusitis Is Associated with Lower Airway Mucus Plugging",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:00Z",
  "url": "https://research.draconitic.com/paper/a1v5sjvx915r5",
  "venue": "Journal of clinical medicine",
  "versions": []
}