{
  "abstract": "New thiosemicarbazones bearing Schiff base (1-7) were prepared from 4-(dimethylamino)benzaldehyde and thiosemicarbazides. The reaction of various isothiocyanates with hydrazine monohydrate resulted in the thiosemicarbazides. The structural frameworks of the newly developed derivatives were confirmed by elemental analysis and conventional spectroscopic methods, namely, FT-IR, ¹H, and ¹³C NMR. The in vitro antioxidant activity of the synthesized series was evaluated using the DPPH• (1,1-diphenyl-2-picrylhydrazyl) scavenging method. The results indicated that the inhibitory concentrations (IC₅₀) of the compounds ranged from 8.50 ± 0.14 to 31.44 ± 1.39 µg/mL, with compound 6 exhibiting the most potent antioxidant activity. Additionally, the inhibitory activities of urease and xanthine oxidase (XO) were assessed, and the interactions of the compounds with these enzymes were also analyzed. Molecular docking was performed to assess the interactions between each molecule and the active sites of urease and XO.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry Education, Faculty of Education, Ondokuz Mayıs University, Samsun, Türkiye.",
    "Department of Chemistry, Faculty of Sciences, Kastamonu University, Kastamonu, Türkiye.",
    "Department of Chemistry, Faculty of Sciences, Ondokuz Mayıs University, Samsun, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hasan Yakan",
      "orcid": "0000-0002-4428-4696"
    },
    {
      "affs": [
        1
      ],
      "name": "Halit Muglu",
      "orcid": "0000-0001-8306-2378"
    },
    {
      "affs": [
        2
      ],
      "name": "Semiha Yenigun",
      "orcid": "0000-0002-1979-5427"
    },
    {
      "affs": [
        2
      ],
      "name": "Tevfik Ozen",
      "orcid": "0000-0003-0133-5630"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a1zy9htsg371q.bib",
  "cited_by": 0,
  "doi": "10.1002/cbdv.71882",
  "fulltext_url": "https://europepmc.org/articles/PMC13720966",
  "id": "a1zy9htsg371q",
  "issns": [
    "1612-1872",
    "1612-1880"
  ],
  "landing_url": "https://europepmc.org/article/MED/42960721",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1605|Synthesis and biological activity"
    ]
  ],
  "openalex": "W7224905352",
  "pdf_url": "https://europepmc.org/articles/PMC13720966?pdf=render",
  "pmcid": "PMC13720966",
  "pmid": "42960721",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a1zy9htsg371q.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42960721",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960721"
    },
    {
      "first_seen": "2026-11-03T12:21:45Z",
      "native_id": "PMC13720966",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cbdv.71882"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Synthesis and biological activity",
      "subfield": "organic"
    }
  ],
  "title": "Preparation, Spectroscopic Elucidation, Antioxidant Potential, Enzyme Inhibition, and Molecular Docking Studies of Novel Schiff Base-Derived Thiosemicarbazones.",
  "title_text": "Preparation, Spectroscopic Elucidation, Antioxidant Potential, Enzyme Inhibition, and Molecular Docking Studies of Novel Schiff Base-Derived Thiosemicarbazones.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:45Z",
  "url": "https://research.draconitic.com/paper/a1zy9htsg371q",
  "venue": "Chemistry & biodiversity",
  "versions": []
}