{
  "abstract": "Background\n\nAnastomotic leak (AL) is a serious complication following colorectal cancer (CRC) resection. Its influence on long-term oncologic outcomes, including recurrence and survival, remains controversial.Methods\n\nThis retrospective cohort study aimed to evaluate the prevalence of AL following CRC resection with anastomosis for stage 1-3 CRC. Clinical, operative, oncologic, and follow-up data were collected. AL was diagnosed within 30 days postoperatively. Primary outcomes included recurrence and mortality.Results\n\nA total of 204 patients were included, of whom 25 (12.3%) developed AL. CRC recurrence occurred in 28.0% of patients with AL compared with 24.6% without AL (p = 0.712). Median time to recurrence was shorter in patients with AL (7 vs. 15 months, p = 0.064). One-year mortality was higher in patients with AL (20.0% vs. 3.9%, p = 0.008), and time to mortality was shorter (7 vs. 35 months, p = 0.048). However, AL was not independently associated with mortality or poor outcome on multivariable analysis.Conclusions\n\nAL following CRC resection was associated with earlier mortality and a trend toward earlier recurrence, although no independent association with long-term oncologic outcomes was demonstrated. A larger prospective study with standardized leak definitions would better clarify the relationships between AL and CRC outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ali Farsi"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohammed Nassif"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/a20k524rgx4v7.bib",
  "cited_by": 0,
  "doi": "10.3390/curroncol33100587",
  "fulltext_url": "https://europepmc.org/articles/PMC13703449",
  "id": "a20k524rgx4v7",
  "issns": [
    "1198-0052",
    "1718-7729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930154",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Colorectal Cancer Surgical Treatments"
    ]
  ],
  "openalex": "W7214995952",
  "pdf_url": "https://europepmc.org/articles/PMC13703449?pdf=render",
  "pmcid": "PMC13703449",
  "pmid": "42930154",
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/a20k524rgx4v7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930154",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930154"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Colorectal Cancer Surgical Treatments",
      "subfield": "oncology"
    }
  ],
  "title": "The Association Between Anastomotic Leak and 5-Year Oncologic Outcomes in Patients Undergoing Colorectal Cancer Resection: A Retrospective Cohort Study.",
  "title_text": "The Association Between Anastomotic Leak and 5-Year Oncologic Outcomes in Patients Undergoing Colorectal Cancer Resection: A Retrospective Cohort Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/a20k524rgx4v7",
  "venue": "Current oncology (Toronto, Ont.)",
  "versions": []
}